Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MT-CO2 | P00403 | 1/20 | 0.51 |
| ▸ | BCL2A1 | Q16548 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | STS | P08842 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5879096 | 0.85 | MT-CO2 (0.40) | MT-CO2CNR2STS | |
| SCHEMBL1242387 | 0.85 | NPC1 (0.40) | MT-CO2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1974012 | 0.85 | MEN1 (0.46) | CYP3A4MEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL12497672 | 0.84 | MT-CO2 (0.40) | MT-CO2KMT2AHTT | |
| SCHEMBL30358877 | 0.83 | BCL2A1 (0.43) | MT-CO2BCL2A1KMT2AGAAHTT | |
| SCHEMBL31464829 | 0.83 | BCL2A1 (0.43) | MT-CO2BCL2A1KMT2AGAAHTT | |
| SCHEMBL3160941 | 0.82 | MT-CO2 (0.38) | MT-CO2 | |
| SCHEMBL3657533 | 0.81 | MT-CO2 (0.46) | MT-CO2BCL2A1CYP3A4MEN1KMT2A | |
| SCHEMBL266144 | 0.81 | MT-CO2 (0.46) | MT-CO2BCL2A1CYP3A4MEN1KMT2A | |
| SCHEMBL14830864 | 0.79 | MT-CO2 (0.38) | MT-CO2CYP3A4GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2760845-A1 | HETEROCYCLIC COMPOUNDS AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER | Amgen Inc. (US) | 2014-08-06 | — | — | EP | disclosed |
| WO-2013049250-A1 | HETEROCYCLIC COMPOUNDS AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2013-04-04 | — | — | WO | disclosed |