Sugi Predict

Sugi Predict / Targets / MT-CO2

MT-CO2

Cytochrome c oxidase subunit 2 · P00403 · MT-CO2 on Sugi Atlas →

18,690 patent compounds predicted against MT-CO2, 13,384 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Tolfenamic Acid Tolfenamic Acid (SCHEMBL25190) 1.00 8/20
SCHEMBL774049 SCHEMBL774049 0.55 6/20
SCHEMBL535670 SCHEMBL535670 0.47 6/20
SCHEMBL95507 SCHEMBL95507 0.46 6/20
SCHEMBL690156 SCHEMBL690156 0.45 6/20
SCHEMBL535669 SCHEMBL535669 0.41 4/20
SCHEMBL691054 SCHEMBL691054 0.39 4/20
SCHEMBL691756 SCHEMBL691756 0.38 4/20
SCHEMBL690218 SCHEMBL690218 0.37 4/20
Valdecoxib Valdecoxib (SCHEMBL3356) 1.00 3/20
Parecoxib Parecoxib (SCHEMBL9529) 0.72 3/20
Parecoxib Parecoxib (SCHEMBL117193) 0.71 3/20
Hydroxylated Derivative Hydroxylated Derivative (SCHEMBL214649) 0.66 3/20
Parecoxib Parecoxib (SCHEMBL117192) 0.61 3/20
SCHEMBL921272 SCHEMBL921272 0.54 3/20
SCHEMBL1272834 SCHEMBL1272834 0.52 3/20
SCHEMBL212638 SCHEMBL212638 0.52 3/20
SCHEMBL1075895 SCHEMBL1075895 0.51 3/20
SCHEMBL1272833 SCHEMBL1272833 0.51 3/20
SCHEMBL195456 SCHEMBL195456 0.50 3/20

Clinical trials — most relevant to MT-CO2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease PHASE3COMPLETED
Clinical Evaluation of the Effect of Metformin in Sepsis PHASE3UNKNOWN
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve) PHASE3WITHDRAWN
A Study of Bezafibrate in Mitochondrial Myopathy PHASE2COMPLETED
Evaluating the Effectiveness of a Dichloroacetate in MELAS Syndrome PHASE2UNKNOWN
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus) PHASE1/PHASE2NOT_YET_RECRUITING
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder PHASE2WITHDRAWN
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)? PHASE1UNKNOWN
Plasma Cytochrome c as Biomarker of Traumatic Injury and Predictor of Outcome nanCOMPLETED
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes nanNOT_YET_RECRUITING
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability. nanUNKNOWN
The Genetics of Diabetes in Southern California Chinese Americans nanWITHDRAWN
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine nanCOMPLETED
The Natural History of Mitochondrial Diseases nanRECRUITING
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC) nanRECRUITING
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
Mitoquines in COPD nanUNKNOWN
Ccf mtDNA as a Neurodegenerative Biomarker nanUNKNOWN
Red Light Ptosis Proof-of-Concept nanUNKNOWN
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases nanRECRUITING
Mitochondrial nt3243 A>G Mutation in Taiwan nanUNKNOWN
Natural History in Primary Mitochondrial Myopathies nanRECRUITING
Natural History Study - Mitochondrial Disease nanRECRUITING
Survey on Supplement Use in Mitochondrial Disease nanCOMPLETED
Mitochondrial DNA Copy Number and Leukocyte Telomere Length as Biomarkers in Type 2 Diabetic Patients nanUNKNOWN
Development of a New Technique for Quantifying Mitochondrial DNA in Single Muscle Fibers nanNOT_YET_RECRUITING
EPI-743 for Mitochondrial Respiratory Chain Diseases nanNO_LONGER_AVAILABLE
A RETROspective Study of Patients With TK2d nanCOMPLETED
Mitochondrial Methylation in Type 2 Diabetes nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a MT-CO2 binder may also engage these)

ProteinNameSimilarity
P50690 — 1.000 P50690 →
Q96127 — 1.000 Q96127 →
P25312 — 1.000 P25312 →
P98037 — 1.000 P98037 →
P26456 — 1.000 P26456 →
Q37605 — 1.000 Q37605 →
Q37472 — 1.000 Q37472 →
P92693 — 1.000 P92693 →
P98038 — 1.000 P98038 →
P26457 — 1.000 P26457 →
P68298 — 1.000 P68298 →
P98020 — 1.000 P98020 →
P26455 — 1.000 P26455 →
P68297 — 0.999 P68297 →
P11948 — 0.999 P11948 →
P98044 — 0.997 P98044 →
P98036 — 0.996 P98036 →
Q7IC90 — 0.995 Q7IC90 →
P50661 — 0.995 P50661 →
P98024 — 0.995 P98024 →
Q9GCE7 — 0.995 Q9GCE7 →
Q37741 — 0.994 Q37741 →
P98019 — 0.994 P98019 →
O03848 — 0.994 O03848 →
P67782 — 0.993 P67782 →
Q38RW5 — 0.993 Q38RW5 →
Q9G2X2 — 0.993 Q9G2X2 →
O21400 — 0.992 O21400 →
P50684 — 0.992 P50684 →
Q38S05 — 0.992 Q38S05 →