Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.66 |
| ▸ | MEN1 | O00255 | 5/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | GFER | P55789 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26334263 | 0.83 | KDM4E (0.76) | KDM4EKMT2AMEN1ALDH1A1GFER | |
| SCHEMBL2799377 | 0.81 | KDM4E (0.71) | KDM4EKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL30172555 | 0.80 | KDM4E (0.63) | KDM4EKMT2AALDH1A1GAAHSD17B10 | |
| SCHEMBL8729784 | 0.80 | KDM4E (0.63) | KDM4EKMT2AALDH1A1GAAHSD17B10 | |
| SCHEMBL15193688 | 0.79 | KDM4E (0.59) | KDM4EKMT2AMEN1ALDH1A1GFER | |
| Hydrochloric Acid SCHEMBL26649422 | 0.78 | KDM4E (0.61) | KDM4EKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL31343793 | 0.78 | KDM4E (0.64) | KDM4EKMT2AMEN1ALDH1A1HSD17B10 | |
| SCHEMBL14177245 | 0.78 | KDM4E (0.59) | KDM4EKMT2AMEN1ALDH1A1HSD17B10 | |
| SCHEMBL14829872 | 0.78 | KDM4E (0.64) | KDM4EKMT2AMEN1ALDH1A1HSD17B10 | |
| SCHEMBL2054591 | 0.78 | KMT2A (0.46) | KDM4EKMT2AMEN1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2760840-A1 | QUINOLINONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE | Bristol-Myers Squibb Company (US) | 2014-08-06 | — | — | EP | disclosed |
| WO-2013048942-A1 | QUINOLINONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-04-04 | — | — | WO | disclosed |