Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30172555 | 1.00 | KDM4E (0.63) | KDM4EALDH1A1HSD17B10HPGDTP53 | |
| Hydrochloric Acid SCHEMBL26649422 | 0.98 | KDM4E (0.61) | KDM4EALDH1A1HSD17B10HPGDTP53 | |
| SCHEMBL14177245 | 0.84 | KDM4E (0.59) | KDM4EALDH1A1HSD17B10HPGDTP53 | |
| SCHEMBL14829872 | 0.84 | KDM4E (0.64) | KDM4EALDH1A1HSD17B10HPGDTP53 | |
| SCHEMBL31343793 | 0.84 | KDM4E (0.64) | KDM4EALDH1A1HSD17B10HPGDTP53 | |
| SCHEMBL13451625 | 0.80 | KDM4E (0.67) | KDM4EALDH1A1HSD17B10HPGDTP53 | |
| SCHEMBL14830559 | 0.80 | KDM4E (0.69) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL2799377 | 0.80 | KDM4E (0.71) | KDM4EALDH1A1HSD17B10HPGDTP53 | |
| SCHEMBL28982768 | 0.79 | KDM4E (0.63) | KDM4EALDH1A1HPGDTDP1POLB | |
| SCHEMBL30020580 | 0.78 | PBRM1 (0.54) | KDM4EALDH1A1HSD17B10HPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240374583-A1 | USE OF MORPHINAN DERIVATIVES FOR TREATMENT OF OPIOID DELTA RECEPTOR AGONIST-RELATED DISEASE | NIPPON CHEMIPHAR CO., LTD (JP) | 2024-11-14 | — | — | US | disclosed |
| US-12109209-B2 | Use of morphinan derivatives for treatment of opioid delta receptor agonist-related disease | NIPPON CHEMIPHAR CO., LTD. (JP) | 2024-10-08 | — | — | US | disclosed |
| EP-4414037-A2 | MORPHINAN DERIVATIVES FOR THE TREATMENT OF OPIOID DELTA RECEPTOR AGONIST-RELATED DISEASES | Nippon Chemiphar Co., Ltd. (JP) | 2024-08-14 | — | — | EP | disclosed |
| EP-3513792-B9 | MORPHINAN DERIVATIVES FOR THE TREATMENT OF OPIOID DELTA RECEPTOR AGONIST-RELATED DISEASES | NIPPON CHEMIPHAR CO (JP) | 2024-07-10 | — | — | EP | disclosed |
| CN-118076593-A | 3CLpro protease inhibitors | 上海齐鲁制药研究中心有限公司 | 2024-05-24 | — | — | CN | disclosed |
| CN-113292559-B | Morphinan derivatives | 日本化学药品株式会社 | 2024-04-02 | — | — | CN | disclosed |
| EP-3513792-B1 | MORPHINAN DERIVATIVES FOR THE TREATMENT OF OPIOID DELTA RECEPTOR AGONIST-RELATED DISEASES | NIPPON CHEMIPHAR CO (JP) | 2024-03-27 | — | — | EP | disclosed |
| CN-117122598-A | Use of morphinan derivatives in the treatment of opioid delta receptor agonist-related diseases | 日本化学药品株式会社 | 2023-11-28 | — | — | CN | disclosed |
| WO-2023219456-A1 | QUINOLINE-BASED HISTONE DEACETYLASE INHIBITORY SUBSTANCES, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME AS ACTIVE INGREDIENT | 숙명여자대학교 산학협력단 | 2023-11-16 | — | — | WO | disclosed |
| CN-110248658-B | Use of morphinan derivatives in the treatment of opioid delta receptor agonist-related diseases | 日本化学药品株式会社 | 2023-10-13 | — | — | CN | disclosed |
| US-7186841-B2 | (2-imidazolyl)quinolin-4-yl aldehydes; immunomodulators, antiproliferative agents; metabolic disorders | AMGEN INC. (US) | 2007-03-06 | — | — | US | disclosed |
| US-5849756-A | Pharmaceutical composition and method for modulating the immune reaction | CERBIOS-PHARMA SA (CH) | 1998-12-15 | — | — | US | disclosed |
| US-5591751-A | CARBOSTYRIL DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-01-07 | — | — | US | disclosed |
| EP-0684231-A1 | Pharmaceutical preparation for modulating immunological reactions and new derivatives of indols and quinoline | Cerbios-Pharma S.A. (CH) | 1995-11-29 | — | — | EP | disclosed |
| CN-1102527-A | Piperazinocarbonylcarbostyrils as peripheral vasodilators | OTSUKA PHARMA CO LTD (JP) | 1995-05-10 | — | — | CN | disclosed |
| EP-0636128-A1 | PIPERAZINOCARBONYLCARBOSTYRILS AS PERIPHERAL VASODILATORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-02-01 | — | — | EP | disclosed |
| US-RE34722-E | Antiulcer agents | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-09-06 | — | — | US | disclosed |
| WO-1994019339-A1 | PIPERAZINOCARBONYLCARBOSTYRILS AS PERIPHERAL VASODILATORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-09-01 | — | — | WO | disclosed |
| US-4578381-A | ANTIULCER AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-03-25 | — | — | US | disclosed |
| US-4008086-A | PYRIDONE OR PYRIDAZONE DERIVATIVES | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JA) | 1977-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240374583-A1 | USE OF MORPHINAN DERIVATIVES FOR TREATMENT OF OPIOID DELTA RECEPTOR AGONIST-RELATED DISEASE | OPRD1, OPRM1, OPRK1 | KDM4E 4829/4885ALDH1A1 1568/4885HSD17B10 2331/4885 |
| US-12109209-B2 | Use of morphinan derivatives for treatment of opioid delta receptor agonist-related disease | OPRD1, OPRM1, OPRK1 | KDM4E 4829/4885ALDH1A1 1568/4885HSD17B10 2331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.