Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 6/20 | 0.37 |
| ▸ | CCR9 | P51686 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1482975 | 0.91 | FFAR4 (0.49) | KDM4EFFAR1FFAR4TBXA2RPTGER1 | |
| SCHEMBL1482665 | 0.87 | KDM4E (0.47) | KDM4EDRD2TBXA2RCCR9HDAC1 | |
| SCHEMBL1482727 | 0.86 | MAPT (0.40) | KDM4EFFAR1FFAR4CCR9P2RX3 | |
| SCHEMBL1482951 | 0.86 | TP53 (0.45) | KDM4EPTGER1CYP1A2CYP2C9HPGD | |
| SCHEMBL1483050 | 0.85 | KDM4E (0.43) | KDM4EDRD2TBXA2RCCR9P2RX3 | |
| SCHEMBL1483423 | 0.84 | NR1H4 (0.42) | KDM4EPTGER1CCR9P2RX3CYP3A4 | |
| SCHEMBL1484288 | 0.84 | KMT2A (0.42) | KDM4EPTGER1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL1482913 | 0.83 | KDM4E (0.48) | KDM4EDRD2TBXA2RCCR9P2RX3 | |
| SCHEMBL1482885 | 0.81 | KDM4E (0.42) | KDM4EDRD2TBXA2RPTGER1HTT | |
| SCHEMBL1482636 | 0.80 | DRD2 (0.52) | DRD2TBXA2RPTGER1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8309581-B2 | Benzimidazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-11-13 | — | — | US | disclosed |
| US-20110077273-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110077273-A1 | NEW BENZIMIDAZOLE DERIVATIVES | BRI3BP, CYP3A4, RB1 | KDM4E 1791/4885FFAR1 1795/4885FFAR4 1845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.