Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 16/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 14/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 10/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14801554 | 1.00 | PIM1 (0.44) | PIM1PIM2PIM3 | |
| SCHEMBL2520959 | 0.86 | PIM2 (0.42) | PIM1PIM2PIM3 | |
| SCHEMBL14800613 | 0.84 | HPGDS (0.42) | PIM1PIM2PIM3 | |
| SCHEMBL14800616 | 0.84 | HPGDS (0.42) | PIM1PIM2PIM3 | |
| SCHEMBL2521182 | 0.83 | MAP4K4 (0.48) | — | |
| SCHEMBL14800313 | 0.82 | PIM1 (0.41) | PIM1PIM2PIM3 | |
| SCHEMBL14800952 | 0.82 | PIM1 (0.41) | PIM1PIM2PIM3 | |
| SCHEMBL14800312 | 0.82 | PIM1 (0.41) | PIM1PIM2PIM3 | |
| SCHEMBL15615354 | 0.82 | PIM1 (0.41) | PIM1PIM2PIM3 | |
| SCHEMBL14802965 | 0.82 | PIM1 (0.41) | PIM1PIM2PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2760857-A1 | PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-06 | — | — | EP | disclosed |
| WO-2013045461-A1 | PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2013-04-04 | — | — | WO | disclosed |