Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.46 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1483214 | 0.83 | KCNQ3 (0.52) | ALDH1A1MAPTKCNQ3KCNQ2AR | |
| SCHEMBL1483919 | 0.81 | AR (0.53) | ALDH1A1NPC1KCNQ3KCNQ2AR | |
| SCHEMBL1483167 | 0.81 | KCNQ3 (0.53) | KCNQ3KCNQ2ARCHEK1 | |
| SCHEMBL3305812 | 0.77 | AR (0.57) | KCNQ3KCNQ2ARCHEK1MAPK1 | |
| SCHEMBL19776339 | 0.75 | KCNQ3 (0.56) | KCNQ3KCNQ2ARCHEK1 | |
| SCHEMBL10465216 | 0.75 | POLB (0.66) | ALDH1A1MAPTKDM4EGAANPC1 | |
| SCHEMBL3949406 | 0.73 | AR (0.52) | MAPTKCNQ3KCNQ2ARKMT2A | |
| SCHEMBL1484387 | 0.73 | HDAC3 (0.50) | ALDH1A1MAPTKDM4EGAANPC1 | |
| SCHEMBL1484386 | 0.73 | HDAC3 (0.50) | ALDH1A1MAPTKDM4EGAANPC1 | |
| SCHEMBL1484389 | 0.73 | HDAC3 (0.60) | ALDH1A1MAPTGAANPC1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8314103-B2 | Pyridyl derivatives, their preparation and use | Piramal Enterprises Limited (IN) | 2012-11-20 | — | — | US | disclosed |
| US-20110077252-A1 | PYRIDYL DERIVATIVES, THEIR PREPARATION AND USE | Piramal Enterprises Limited (IN) | 2011-03-31 | — | — | US | disclosed |
| WO-2009019656-A1 | PYRIDYL DERIVATIVES, THEIR PREPARATION AND USE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2009-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110077252-A1 | PYRIDYL DERIVATIVES, THEIR PREPARATION AND USE | HIF1AN, HIF1A, MTOR | ALDH1A1 2458/4885MAPT 3981/4885KDM4E 1669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.