Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 13/20 | 0.40 |
| ▸ | RAF1 | P04049 | 5/20 | 0.32 |
| ▸ | BRAF | P15056 | 5/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17414335 | 0.96 | CETP (0.38) | CETPRAF1BRAFPIK3CA | |
| SCHEMBL14833492 | 0.93 | CETP (0.39) | CETPRAF1BRAFHDAC1PIK3CA | |
| SCHEMBL17414336 | 0.90 | CETP (0.37) | CETPRAF1BRAFPIK3CA | |
| SCHEMBL16124231 | 0.89 | CRHR1 (0.34) | CETP | |
| SCHEMBL14602959 | 0.87 | CETP (0.36) | CETP | |
| SCHEMBL18636599 | 0.86 | CETP (0.34) | CETP | |
| SCHEMBL14833658 | 0.84 | MCHR1 (0.33) | CETP | |
| SCHEMBL15702949 | 0.84 | CETP (0.33) | CETP | |
| SCHEMBL14837800 | 0.83 | CETP (0.33) | CETP | |
| SCHEMBL14602961 | 0.83 | CETP (0.42) | CETPHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2760864-B1 | 5-BENZYLAMINOMETHYL-6-AMINOPYRAZOLO[3,4-b]PYRIDINE DERIVATIVES AS CHOLESTERYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS USEFUL FOR THE TREATMENT OF ATHEROSCLEROSIS | Dr Reddys Laboratories Ltd (IN) | 2018-01-24 | — | — | EP | disclosed |
| US-20170071930-A1 | PHARMACEUTICAL COMPOSITIONS OF CETP INHIBITORS | DR. REDDY'S LABORATORIES, LTD. (IN) | 2017-03-16 | — | — | US | disclosed |
| US-20160000799-A1 | PHARMACEUTICAL COMPOSITIONS OF CETP INHIBITORS | DR. REDDY'S LABORATORIES, LTD. (IN) | 2016-01-07 | — | — | US | disclosed |
| US-20160000799-A1 | PHARMACEUTICAL COMPOSITIONS OF CETP INHIBITORS | DR. REDDY'S LABORATORIES, LTD. (IN) | 2016-01-07 | — | — | US | disclosed |
| US-9000007-B2 | 5-benzylaminomethyl-6-aminopyrazolo [3, 4 -B] pyridine derivatives as cholesteryl ester-transfer protein (CETP) inhibitors useful for the treatment of atherosclerosis | DR. REDDY'S LABORATORIES LTD. (IN) | 2015-04-07 | — | — | US | disclosed |
| US-9000007-B2 | 5-benzylaminomethyl-6-aminopyrazolo [3, 4 -B] pyridine derivatives as cholesteryl ester-transfer protein (CETP) inhibitors useful for the treatment of atherosclerosis | DR. REDDY'S LABORATORIES LTD. (IN) | 2015-04-07 | — | — | US | disclosed |
| US-20140288072-A1 | 5 - BENZYLAMINOMETHYL - 6 - AMINOPYRAZOLO [3, 4 -B] PYRIDINE DERIVATIVES AS CHOLESTERYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS USEFUL FOR THE TREATMENT OF ATHEROSCLEROSIS | DR. REDDY'S LABORATORIES, LTD. (IN) | 2014-09-25 | — | — | US | disclosed |
| US-20140288072-A1 | 5 - BENZYLAMINOMETHYL - 6 - AMINOPYRAZOLO [3, 4 -B] PYRIDINE DERIVATIVES AS CHOLESTERYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS USEFUL FOR THE TREATMENT OF ATHEROSCLEROSIS | DR. REDDY'S LABORATORIES, LTD. (IN) | 2014-09-25 | — | — | US | disclosed |
| WO-2014128564-A2 | PHARMACEUTICAL COMPOSITIONS OF CETP INHIBITORS | DR. REDDY'S LABORATORIES LTD. (IN) | 2014-08-28 | — | — | WO | disclosed |
| EP-2760864-A1 | 5 - BENZYLAMINOMETHYL - 6 - AMINOPYRAZOLO [3, 4 -B]PYRIDINE DERIVATIVES AS CHOLESTERYL ESTER -TRANSFER PROTEIN (CETP) INHIBITORS USEFUL FOR THE TREATMENT OF ATHEROSCLEROSIS | Dr. Reddy's Laboratories Ltd. (IN) | 2014-08-06 | — | — | EP | disclosed |
| WO-2014076568-A2 | PHARMACEUTICAL COMPOSITIONS OF CETP INHIBITORS | DR. REDDY'S LABORATORIES LTD. (IN) | 2014-05-22 | — | — | WO | disclosed |
| WO-2013046045-A1 | 5 - BENZYLAMINOMETHYL - 6 - AMINOPYRAZOLO [3, 4 -B] PYRIDINE DERIVATIVES AS CHOLESTERYL ESTER -TRANSFER PROTEIN (CETP) INHIBITORS USEFUL FOR THE TREATMENT OF ATHEROSCLEROSIS | DR. REDDY'S LABORATORIES, LTD. (IN) | 2013-04-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140288072-A1 | 5 - BENZYLAMINOMETHYL - 6 - AMINOPYRAZOLO [3, 4 -B] PYRIDINE DERIVATIVES AS CHOLESTERYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS USEFUL FOR THE TREATMENT OF ATHEROSCLEROSIS | CETP, MTTP, HDLBP | CETP 1/4885RAF1 2475/4885BRAF 4114/4885 |
| US-20160000799-A1 | PHARMACEUTICAL COMPOSITIONS OF CETP INHIBITORS | CETP, LCAT, MTTP | CETP 1/4885RAF1 4363/4885BRAF 4849/4885 |
| US-20170071930-A1 | PHARMACEUTICAL COMPOSITIONS OF CETP INHIBITORS | CETP, NPC1, CES1 | CETP 1/4885RAF1 4001/4885BRAF 4756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.