SCHEMBL14833994

SCHEMBL14833994

Cn1c(CCCC(=O)O)nc2cc(N(CCCl)CCOC(=O)CCCc3nc4cc(CN(CCCl)CCCl)ccc4[nH]3)ccc21

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 5/20 0.62
HDAC1 Q13547 3/20 0.62
HDAC3 O15379 2/20 0.62
HDAC4 P56524 2/20 0.62
HDAC2 Q92769 2/20 0.62
HDAC8 Q9BY41 2/20 0.62
HDAC5 Q9UQL6 2/20 0.62
PTGS1 P23219 1/20 0.62
HDAC10 Q969S8 1/20 0.62
ALDH1A1 P00352 4/20 0.37
MAPT P10636 2/20 0.37
GMNN O75496 1/20 0.37
LMNA P02545 1/20 0.37
CYP2D6 P10635 1/20 0.37
GABRA1 P14867 1/20 0.37
TSHR P16473 1/20 0.37
NFKB1 P19838 1/20 0.37
THPO P40225 1/20 0.37
GABRA2 P47869 1/20 0.37
GABRB2 P47870 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL229341 0.86 HDAC6 (0.83) HDAC6HDAC1HDAC3HDAC4HDAC2
SCHEMBL14833991 0.85 HDAC6 (0.62) HDAC6HDAC1HDAC3HDAC4HDAC2
SCHEMBL8400628 0.83 HDAC6 (0.78) HDAC6HDAC1HDAC3HDAC4HDAC2
SCHEMBL17010793 0.80 HDAC6 (0.71) HDAC6HDAC1HDAC3HDAC4HDAC2
SCHEMBL20220236 0.80 HDAC6 (0.83) HDAC6HDAC1HDAC3HDAC4HDAC2
SCHEMBL14700719 0.79 HDAC6 (0.69) HDAC6HDAC1HDAC3HDAC4HDAC2
Bendamustine SCHEMBL26319 0.79 HDAC6 (1.00) HDAC6HDAC1HDAC3HDAC4HDAC2
Bendamustine SCHEMBL29394147 0.79 HDAC6 (1.00) HDAC6HDAC1HDAC3HDAC4HDAC2
Bendamustine SCHEMBL9950832 0.79 HDAC6 (1.00) HDAC6HDAC1HDAC3HDAC4HDAC2
SCHEMBL14823504 0.78 HDAC6 (0.73) HDAC6HDAC1HDAC3HDAC4HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2575784-A1 ORAL DOSAGE FORMS OF BENDAMUSTINE Astellas Deutschland GmbH (DE) 2013-04-10 EP disclosed