Bendamustine

Bendamustine

SCHEMBL26319

Cn1c(CCCC(=O)O)nc2cc(N(CCCl)CCCl)ccc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 7/20 1.00
HDAC1 Q13547 4/20 1.00
HDAC3 O15379 2/20 1.00
HDAC4 P56524 2/20 1.00
HDAC2 Q92769 2/20 1.00
HDAC8 Q9BY41 2/20 1.00
HDAC5 Q9UQL6 2/20 1.00
PTGS1 P23219 1/20 1.00
HDAC10 Q969S8 1/20 1.00
ALDH1A1 P00352 2/20 0.52
GMNN O75496 1/20 0.52
LMNA P02545 1/20 0.52
CYP2D6 P10635 1/20 0.52
MAPT P10636 1/20 0.52
GABRA1 P14867 1/20 0.52
TSHR P16473 1/20 0.52
NFKB1 P19838 1/20 0.52
THPO P40225 1/20 0.52
GABRA2 P47869 1/20 0.52
GABRB2 P47870 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bendamustine SCHEMBL29394147 1.00 HDAC6 (1.00) HDAC6HDAC1HDAC3HDAC4HDAC2
Bendamustine SCHEMBL9950832 1.00 HDAC6 (1.00) HDAC6HDAC1HDAC3HDAC4HDAC2
Bendamustine SCHEMBL15523734 0.99 HDAC6 (0.98) HDAC6HDAC1HDAC3HDAC4HDAC2
Bendamustine SCHEMBL12497247 0.99 HDAC6 (0.98) HDAC6HDAC1HDAC3HDAC4HDAC2
Bendamustine SCHEMBL18843 0.99 HDAC6 (0.98) HDAC6HDAC1HDAC3HDAC4HDAC2
Bendamustine SCHEMBL29352819 0.99 HDAC6 (0.98) HDAC6HDAC1HDAC3HDAC4HDAC2
Bendamustine SCHEMBL15436003 0.98 HDAC6 (0.96) HDAC6HDAC1HDAC3HDAC4HDAC2
Bendamustine SCHEMBL118499 0.98 HDAC6 (0.96) HDAC6HDAC1HDAC3HDAC4HDAC2
SCHEMBL16772708 0.97 HDAC6 (0.94) HDAC6HDAC1HDAC3HDAC4HDAC2
Bendamustine SCHEMBL23909358 0.96 HDAC6 (0.92) HDAC6HDAC1HDAC3HDAC4HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 35584 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116209439-B Cereblon protein modulators Saint Jude Children's Research Hospital Ltd. (US) 2026-05-26 CN claimed
WO-2026105121-A1 ANTICANCER FORMULATIONS AND USES THEREOF INTRAGEL THERAPEUTICS LTD. (IL) 2026-05-21 WO claimed
US-20260137685-A1 SOLID PHARMACEUTICAL FORMULATION OF PARP INHIBITORS AND USE THEREOF IMPACT THERAPEUTICS SHANGHAI INC (CN) 2026-05-21 US claimed
US-20260137686-A1 SOLID PHARMACEUTICAL FORMULATION OF PARP INHIBITORS AND USE THEREOF IMPACT THERAPEUTICS SHANGHAI INC (CN) 2026-05-21 US claimed
US-20260139071-A1 Subcutaneous Formulations Of Anti-CD38 Antibodies And Their Uses JANSSEN BIOTECH INC (US) 2026-05-21 US claimed
WO-2026107377-A1 PHARMACOLOGICAL RE-ACTIVATION OF MUTANT PVHL KARANICOLAS JOHN (US) 2026-05-21 WO claimed
EP-3841097-B1 2,6-BIS(((1H-BENZO[D]IMIDAZOL-2-YL)THIO)METHYL)PYRIDINE AND N2,N6-DIBENZYLPYRIDINE-2,6-DICARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE (PI3K) INHIBITORS FOR TREATING CANCER BIOMEDICAL RES FOUNDATION OF THE ACADEMY OF ATHENS BRFAA (GR) 2026-05-20 EP claimed
US-12630603-B2 Chimeric antigen receptor T cell therapy KITE PHARMA, INC. (US) 2026-05-19 US claimed
CN-122055366-A GCN2 and PERK kinase modulators and methods of use thereof 德西费拉制药有限责任公司 2026-05-15 CN claimed
WO-2026102456-A1 METHODS OF TREATING CANCER BY ADMINISTERING BISPECIFIC CD19/CD20 CAR T CELLS LYELL IMMUNOPHARMA, INC. (US) 2026-05-15 WO claimed
EP-1444989-A1 Sensitizing cells for apoptosis by selectively blocking cytokines Stassi, Giorgio, Dr. (IT) 2004-08-11 EP claimed
US-20040152672-A1 Indole compounds useful for the treatment of cancer NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2004-08-05 US claimed
EP-1435877-A1 COATING OF STENTS FOR PREVENTING RESTENOSIS Hemoteq GmbH (DE) 2004-07-14 EP claimed
US-20040072889-A1 Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia PHARMACIA CORPORATION 2004-04-15 US claimed
WO-2003094990-A1 COMPOUNDS AND METHOD FOR COATING SURFACES IN A HAEMOCOMPATIBLE MANNER HEMOTEQ GMBH (DE) 2003-11-20 WO claimed
WO-2003086470-A2 SMAC-PEPTIDES AS THERAPEUTICS AGAINST CANCER AND AUTOIMMUNE DISEASES DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) 2003-10-23 WO claimed
EP-1354952-A1 Smac-peptides as therapeutics against cancer and autoimmune diseases Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) 2003-10-22 EP claimed
EP-1354953-A1 Smac-peptides as therapeutics against cancer and autoimmune diseases Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) 2003-10-22 EP claimed
WO-2003081238-A2 CYTOCAPACITY TEST Ludwig Maximilians Universität (DE) 2003-10-02 WO claimed
WO-2003034944-A1 COATING OF STENTS FOR PREVENTING RESTENOSIS HEMOTEQ GMBH (DE) 2003-05-01 WO claimed