SCHEMBL1483540

SCHEMBL1483540

NC(=O)C(c1ccccc1)C(F)(F)F

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 3/20 0.46
CYP2D6 P10635 2/20 0.43
SRC P12931 1/20 0.43
ATM Q13315 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
LMNA P02545 3/20 0.41
MAPK1 P28482 2/20 0.41
CYP1A2 P05177 1/20 0.41
PKM P14618 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
ALOX5 P09917 1/20 0.41
CTSD P07339 1/20 0.41
ADORA3 P0DMS8 1/20 0.40
EDNRB P24530 1/20 0.40
MC4R P32245 1/20 0.40
CYP2C19 P33261 1/20 0.40
DRD3 P35462 1/20 0.40
MC3R P41968 1/20 0.40
SLC6A3 Q01959 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8413696 0.98 EPHX1 (0.44) EPHX1CYP2D6SRCATML3MBTL1
SCHEMBL4026079 0.84 SRC (0.50) CYP2D6SRCATML3MBTL1LMNA
SCHEMBL28044484 0.84 CYP2D6 (0.44) CYP2D6SRCATML3MBTL1LMNA
SCHEMBL7955519 0.84 SRC (0.50) CYP2D6SRCATML3MBTL1LMNA
SCHEMBL195532 0.84 SRC (0.50) CYP2D6SRCATML3MBTL1LMNA
SCHEMBL6971672 0.83 CYP2D6 (0.43) CYP2D6SRCATML3MBTL1LMNA
Hydrochloric Acid SCHEMBL2529822 0.83 SRC (0.48) CYP2D6SRCATML3MBTL1LMNA
SCHEMBL29773675 0.83 SRC (0.48) CYP2D6SRCATML3MBTL1LMNA
SCHEMBL9153046 0.81 CYP2D6 (0.41) CYP2D6SRCATML3MBTL1LMNA
SCHEMBL12458246 0.81 ATM (0.44) CYP2D6SRCATML3MBTL1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105392363-B Sample Fixation and Stabilization A·S·戈尔兹伯勒 2017-09-29 CN claimed
CN-105392363-A Sample Fixation and Stabilization GOLDSBOROUGH ANDREW SIMON 2016-03-09 CN claimed
EP-1286967-B1 CYCLOHEXANE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS MERCK SHARP & DOHME (GB) 2006-09-27 EP claimed
CN-116354830-A Process for the preparation of functionalized fluorinated monomers, fluorinated monomers and compositions for the preparation thereof 埃特纳科技有限公司 2023-06-30 CN disclosed
CN-106421793-B Compositions and methods for treating centrally mediated nausea and vomiting 赫尔森保健股份公司 2023-06-16 CN disclosed
CN-110770271-B Method for preparing functionalized fluorinated monomers, fluorinated monomers and compositions for preparing same 埃特纳科技有限公司 2023-04-18 CN disclosed
WO-2023035571-A1 SYNTHESIS METHOD FOR ESAXERENONE AND INTERMEDIATE THEREOF 上海鼎雅药物化学科技有限公司 2023-03-16 WO disclosed
CN-115784961-A Synthesis method of oxacillin and intermediate thereof 上海鼎雅药物化学科技有限公司 2023-03-14 CN disclosed
CN-115322131-A Synthesis method of beta-fluoroindole acrylamide compound 温州大学 2022-11-11 CN disclosed
EP-3788873-A1 SAMPLE FIXATION AND STABILISATION Goldsborough, Andrew Simon (FR) 2021-03-10 EP disclosed
WO-2020244968-A1 FUNGICIDAL N-(PYRID-3-YL)CARBOXAMIDES BASF SE (DE) 2020-12-10 WO disclosed
WO-2004058762-A1 MITOGEN ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE-2 INHIBITING COMPOUNDS PHARMACIA CORPORATION (US) 2004-07-15 WO disclosed
WO-2003043983-A1 PIPERAZINE DERIVATIVES DESTABILISING ANDROGEN RECEPTORS SCHERING AKTIENGESELLSCHAFT (DE) 2003-05-30 WO disclosed
EP-1173420-A2 HETEROCYCLIC COMPOUNDS HAVING ANTITUMOR ACTIVITY Novuspharma S.p.A. (IT) 2002-01-23 EP disclosed
WO-2000053581-A2 HETEROCYCLIC COMPOUNDS HAVING ANTITUMOR ACTIVITY NOVUSPHARMA S.P.A. (IT) 2000-09-14 WO disclosed
EP-0066483-B1 METHOD FOR THE PREPARATION OF ALIPHATIC OR AROMATIC NITRILES RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1984-11-21 EP disclosed
EP-0065447-B1 FLUOR-CONTAINING SILICA CATALYSTS; THEIR PREPARATION, AND THEIR USE IN THE PREPARATION OF NITRILES RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1984-09-05 EP disclosed
EP-0066482-A1 Method for the preparation of aliphatic or aromatic nitriles RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1982-12-08 EP disclosed
EP-0066483-A1 Method for the preparation of aliphatic or aromatic nitriles RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1982-12-08 EP disclosed
EP-0065447-A1 Fluor-containing silica catalysts; their preparation, and their use in the preparation of nitriles RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1982-11-24 EP disclosed