Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 13/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.51 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.48 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL14836576 | 1.00 | DPP4 (0.51) | DPP4CYP3A4DPP8DPP7CYP2D6 | |
| Fumaric Acid SCHEMBL14836575 | 1.00 | DPP4 (0.51) | DPP4CYP3A4DPP8DPP7CYP2D6 | |
| SCHEMBL15859334 | 0.96 | DPP4 (0.53) | DPP4CYP3A4DPP8DPP7CYP2D6 | |
| SCHEMBL15100250 | 0.96 | DPP4 (0.53) | DPP4CYP3A4DPP8DPP7CYP2D6 | |
| Fumaric Acid SCHEMBL14836806 | 0.90 | DPP4 (0.56) | DPP4CYP3A4DPP8DPP7DPP9 | |
| Fumaric Acid SCHEMBL14836381 | 0.90 | DPP4 (0.53) | DPP4CYP3A4DPP8DPP7DPP9 | |
| Fumaric Acid SCHEMBL14836805 | 0.90 | DPP4 (0.56) | DPP4CYP3A4DPP8DPP7DPP9 | |
| Fumaric Acid SCHEMBL14836803 | 0.90 | DPP4 (0.56) | DPP4CYP3A4DPP8DPP7DPP9 | |
| Fumaric Acid SCHEMBL14836383 | 0.90 | DPP4 (0.53) | DPP4CYP3A4DPP8DPP7DPP9 | |
| Fumaric Acid SCHEMBL14836386 | 0.90 | DPP4 (0.53) | DPP4CYP3A4DPP8DPP7DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8785477-B2 | Hexahydropyrrolo[3,4-b]pyrrole derivatives, preparation methods and pharmaceutical uses thereof | SHANGHAI SUN-SAIL PHARMACEUTICAL SCIENCE & TECHNOLOGY CO., LTD. (CN) | 2014-07-22 | — | — | US | claimed |
| EP-2578586-B1 | HEXAHYDROPYRROLO[3,4-b]PYRROLE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF | SHANGHAI SUN SAIL PHARMACEUTICAL SCIENCE & TECHNOLOGY CO LTD (CN) | 2014-07-09 | — | — | EP | claimed |
| US-20130178500-A1 | HEXAHYDROPYRROLO[3,4-b]PYRROLE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF | JIANGSU JINGLIXIN PHARMACEUTICAL TECHNOLOGY CO.,LTD. (CN) | 2013-07-11 | — | — | US | claimed |
| US-8785477-B2 | Hexahydropyrrolo[3,4-b]pyrrole derivatives, preparation methods and pharmaceutical uses thereof | SHANGHAI SUN-SAIL PHARMACEUTICAL SCIENCE & TECHNOLOGY CO., LTD. (CN) | 2014-07-22 | — | — | US | disclosed |
| EP-2578586-B1 | HEXAHYDROPYRROLO[3,4-b]PYRROLE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF | SHANGHAI SUN SAIL PHARMACEUTICAL SCIENCE & TECHNOLOGY CO LTD (CN) | 2014-07-09 | — | — | EP | disclosed |
| US-20130178500-A1 | HEXAHYDROPYRROLO[3,4-b]PYRROLE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF | JIANGSU JINGLIXIN PHARMACEUTICAL TECHNOLOGY CO.,LTD. (CN) | 2013-07-11 | — | — | US | disclosed |
| EP-2578586-A1 | HEXAHYDROPYRROLO[3,4-b]PYRROLE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF | Shanghai Sun-Sail Pharmaceutical Science & Technology Co., Ltd (CN) | 2013-04-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130178500-A1 | HEXAHYDROPYRROLO[3,4-b]PYRROLE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF | DPP4, DPP3, DPP7 | DPP4 1/4885CYP3A4 82/4885DPP8 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.