Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.52 |
| ▸ | CDC7 | O00311 | 7/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.45 |
| ▸ | CDK2 | P24941 | 7/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.45 |
| ▸ | DBF4 | Q9UBU7 | 7/20 | 0.45 |
| ▸ | CCNC | P24863 | 2/20 | 0.45 |
| ▸ | CDK8 | P49336 | 2/20 | 0.45 |
| ▸ | CLK1 | P49759 | 2/20 | 0.45 |
| ▸ | DAPK1 | P53355 | 2/20 | 0.45 |
| ▸ | DMPK | Q09013 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.45 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.45 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 3/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 6/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14447537 | 0.77 | KCNH2 (0.48) | HCRTR1HCRTR2NPC1RAB9A | |
| SCHEMBL8273965 | 0.74 | SCN10A (0.55) | SCN10ACDC7CCNE1CDK2ROCK1 | |
| SCHEMBL19488467 | 0.74 | SCN10A (0.59) | SCN10ACDC7CCNE1CDK2ROCK1 | |
| SCHEMBL12684295 | 0.74 | SCN10A (0.59) | SCN10ACDC7CCNE1CDK2ROCK1 | |
| SCHEMBL15585670 | 0.74 | SCN10A (0.70) | SCN10ACDC7CCNE1CDK2ROCK1 | |
| SCHEMBL15746270 | 0.74 | SCN10A (0.70) | SCN10ACDC7CCNE1CDK2ROCK1 | |
| SCHEMBL15844574 | 0.73 | SCN10A (0.58) | SCN10ACDC7CCNE1CDK2ROCK1 | |
| SCHEMBL15844575 | 0.73 | SCN10A (0.58) | SCN10ACDC7CCNE1CDK2ROCK1 | |
| SCHEMBL13350394 | 0.73 | SCN10A (0.51) | SCN10ACDC7CCNE1CDK2ROCK1 | |
| SCHEMBL15585625 | 0.73 | SCN10A (0.61) | SCN10ACDC7CCNE1CDK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9527850-B2 | Benzyl piperidine compounds as lysophosphatidic acid (LPA) receptor antagonist | MERCK PATENT GMBH (DE) | 2016-12-27 | — | — | US | disclosed |
| US-9527850-B2 | Benzyl piperidine compounds as lysophosphatidic acid (LPA) receptor antagonist | MERCK PATENT GMBH (DE) | 2016-12-27 | — | — | US | disclosed |
| EP-2844648-B1 | BENZYL PIPERIDINE COMPOUNDS AS LYSOPHOSPHATIDIC ACID (LPA) RECEPTOR ANTAGONIST | MERCK PATENT GMBH (DE) | 2016-11-09 | — | — | EP | disclosed |
| US-20150011557-A1 | Benzyl Piperidine Compounds as Lysophosphatidic Acid (LPA) Receptor Antagonist | MERCK PATENT GMBH (DE) | 2015-01-08 | — | — | US | disclosed |
| US-20150011557-A1 | Benzyl Piperidine Compounds as Lysophosphatidic Acid (LPA) Receptor Antagonist | MERCK PATENT GMBH (DE) | 2015-01-08 | — | — | US | disclosed |
| WO-2013045028-A9 | BENZYL PIPERIDINE COMPOUNDS AS LYSOPHOSPHATIDIC ACID (LPA) RECEPTOR ANTAGONIST | MERCK PATENT GMBH (DE) | 2014-12-24 | — | — | WO | disclosed |
| WO-2013045028-A1 | BENZYL PIPERIDINE COMPOUNDS AS LYSOPHOSPHATIDIC ACID (LPA) RECEPTOR ANTAGONIST | MERCK PATENT GMBH (DE) | 2013-04-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150011557-A1 | Benzyl Piperidine Compounds as Lysophosphatidic Acid (LPA) Receptor Antagonist | LPAR1, LPAR2, LPAR5 | SCN10A 2702/4885CDC7 3510/4885CCNE1 2211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.