Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 10/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 10/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5407734 | 0.88 | NPY5R (0.50) | NPC1RAB9ANPY5R | |
| SCHEMBL14447476 | 0.88 | NPC1 (0.50) | NPC1RAB9AALDH1A1 | |
| SCHEMBL19197040 | 0.85 | KCNH2 (0.47) | KCNH2ALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL14838875 | 0.77 | SCN10A (0.52) | NPC1RAB9AHCRTR1HCRTR2 | |
| SCHEMBL12209610 | 0.77 | ALDH1A1 (0.57) | NPC1RAB9ANPY5RALDH1A1 | |
| SCHEMBL2111216 | 0.77 | NPC1 (0.58) | NPC1RAB9AALDH1A1 | |
| SCHEMBL14447538 | 0.77 | NPC1 (0.51) | NPC1RAB9ANPY5RALDH1A1 | |
| SCHEMBL4348190 | 0.76 | CACNA1G (0.37) | KCNH2HCRTR1HCRTR2 | |
| SCHEMBL20992046 | 0.74 | NPC1 (0.68) | NPC1RAB9A | |
| SCHEMBL16599521 | 0.73 | NPY5R (0.44) | NPC1RAB9ANPY5RALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7244847-B2 | Benzimidazole compounds | ISIS PHARMACEUTICALS, INC. (US) | 2007-07-17 | — | — | US | disclosed |
| US-7244847-B2 | Benzimidazole compounds | ISIS PHARMACEUTICALS, INC. (US) | 2007-07-17 | — | — | US | disclosed |