⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Charcoal, Activated SCHEMBL30289892 | 1.00 | ALDH1A1 (0.91) | — | |
| Charcoal, Activated SCHEMBL318468 | 1.00 | — | — | |
| SCHEMBL1331930 | 0.95 | — | — | |
| SCHEMBL20661241 | 0.95 | ALDH1A1 (1.00) | — | |
| SCHEMBL14855 | 0.95 | — | — | |
| SCHEMBL322832 | 0.95 | ALDH1A1 (1.00) | — | |
| SCHEMBL7091146 | 0.91 | — | — | |
| SCHEMBL11504181 | 0.91 | — | — | |
| Ethylene SCHEMBL8752751 | 0.91 | — | — | |
| Bromide SCHEMBL8198603 | 0.91 | ALDH1A1 (0.91) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130137760-A1 | GAMBOGIC AMINE, A SELECTIVE TRKA AGONIST WITH NEUROPROTECTIVE ACTIVITY | EMORY UNIVERSITY (US) | 2013-05-30 | — | — | US | disclosed |
| US-20110077293-A1 | GAMBOGIC AMINE, A SELECTIVE TrkA AGONIST WITH NEUROPROTECTIVE ACTIVITY | EMORY UNIVERSITY (US) | 2011-03-31 | — | — | US | disclosed |
| CN-101821262-A | Gambogic amide, a kind of selectivity TrkA agonist with neuroprotective activity | UNIV EMORY | 2010-09-01 | — | — | CN | disclosed |
| EP-1180991-B1 | GAMBOGIC ACID DERIVATIVES AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS | CYTOVIA INC (US) | 2010-05-19 | — | — | EP | disclosed |
| US-7622497-B2 | Derivatives of gambogic acid and analogs as activators of caspases and inducers of apoptosis | CYTOVIA, INC. (US) | 2009-11-24 | — | — | US | disclosed |
| US-20090163577-A1 | METHODS AND COMPOSITIONS FOR ANTAGONIZING ANTI-APOPTOTIC Bcl-2-FAMILY PROTEINS | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-06-25 | — | — | US | disclosed |
| WO-2009036068-A2 | GAMBOGIC AMINE, A SELECTIVE TRKA AGONIST WITH NEUROPROTECTIVE ACTIVITY | EMORY UNIVERSITY (US) | 2009-03-19 | — | — | WO | disclosed |
| WO-2008148008-A1 | HIGH THROUGHPUT BIOASSAY FOR IDENTIFYING SELECTIVE TRKA RECEPTOR AGONISTS, AND GAMBOGIC AMIDE, A SELECTIVE TRKA AGONIST WITH NEUROPROTECTIVE ACTIVITY | EMORY UNIVERSITY (US) | 2008-12-04 | — | — | WO | disclosed |
| US-20070093456-A1 | Derivatives of gambogic acid and analogs as activators of caspases and inducers of apoptosis | CYTOVIA, INC. | 2007-04-26 | — | — | US | disclosed |
| US-7176234-B2 | Anticancer agents; side effect reduction | CYTOVIA, INC. (US) | 2007-02-13 | — | — | US | disclosed |
| EP-1180991-A4 | GAMBOGIC ACID, ANALOGS AND DERIVATIVES AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS | CYTOVIA INC (US) | 2005-10-12 | — | — | EP | disclosed |
| EP-1562598-A2 | DERIVATIVES OF GAMBOGIC ACID AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS | Cytovia, Inc. (US) | 2005-08-17 | — | — | EP | disclosed |
| WO-2005060663-A2 | DERIVATIVES OF GAMBOGIC ACID AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS | CYTOVIA, INC. (US) | 2005-07-07 | — | — | WO | disclosed |
| US-20040082066-A1 | Derivatives of gambogic acid and analogs as activators of caspases and inducers of apoptosis | CYTOVIA, INC. | 2004-04-29 | — | — | US | disclosed |
| WO-2004002428-A2 | DERIVATIVES OF GAMBOGIC ACID AND INDUCE APOPTOSIS | CYTOVIA, INC. (US) | 2004-01-08 | — | — | WO | disclosed |
| US-6613762-B2 | Synergystic mixtures comprising prodrugs, 9,10-dihydrogambogic acid and antibodies, cell growth factors or cytokines, used as anticarcinogenic agents | CYTOVIA, INC. | 2003-09-02 | — | — | US | disclosed |
| US-20030078292-A1 | Gambogic acid, analogs and derivatives as activators of caspases and inducers of apoptosis | CYTOVIA, INC. | 2003-04-24 | — | — | US | disclosed |
| US-6462041-B1 | ACTIVATORS OF CASPASE CASCADE; TREATING, PREVENTING OR AMELIORATING NEOPLASIA AND CANCER | CYTOVIA, INC. | 2002-10-08 | — | — | US | disclosed |
| EP-1180991-A2 | GAMBOGIC ACID, ANALOGS AND DERIVATIVES AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS | Cytovia, Inc. (US) | 2002-02-27 | — | — | EP | disclosed |
| WO-2000044216-A2 | GAMBOGIC ACID, ANALOGS AND DERIVATIVES AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS | CYTOVIA INC (US) | 2000-08-03 | — | — | WO | disclosed |