Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 12/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14840216 | 0.83 | GRM5 (0.44) | ARGRM5OPRL1OPRM1 | |
| SCHEMBL17912958 | 0.79 | AR (0.52) | ARGRM5OPRL1OPRM1RAB9A | |
| SCHEMBL14840259 | 0.75 | GRM5 (0.47) | GRM5 | |
| SCHEMBL2518615 | 0.74 | GRM5 (0.45) | ARGRM5OPRL1OPRM1 | |
| SCHEMBL16702383 | 0.74 | AR (0.54) | ARGRM5OPRL1OPRM1RAB9A | |
| SCHEMBL14840553 | 0.73 | CHRNB2 (0.43) | CHRNB2CHRNA4OPRM1SMN1; SMN2 | |
| SCHEMBL14843988 | 0.73 | CHRNB2 (0.43) | ARGRM5CHRNB2CHRNA4 | |
| SCHEMBL16264819 | 0.72 | AR (0.52) | ARGRM5OPRL1OPRM1RAB9A | |
| SCHEMBL27913504 | 0.72 | AR (0.51) | ARGRM5OPRL1OPRM1RAB9A | |
| SCHEMBL14840395 | 0.71 | GRM5 (0.67) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763977-B1 | ETHYNYL DERIVATIVES AS MGLUR5 ALLOSTERIC MODULATORS | HOFFMANN LA ROCHE (CH) | 2016-02-24 | — | — | EP | disclosed |
| EP-2763977-B1 | ETHYNYL DERIVATIVES AS MGLUR5 ALLOSTERIC MODULATORS | HOFFMANN LA ROCHE (CH) | 2016-02-24 | — | — | EP | disclosed |
| US-8969338-B2 | Ethynyl derivatives | HOFFMANN-LA ROCHE INC. (US) | 2015-03-03 | — | — | US | disclosed |
| US-8969338-B2 | Ethynyl derivatives | HOFFMANN-LA ROCHE INC. (US) | 2015-03-03 | — | — | US | disclosed |
| US-8969338-B2 | Ethynyl derivatives | HOFFMANN-LA ROCHE INC. (US) | 2015-03-03 | — | — | US | disclosed |
| EP-2763977-A1 | ETHYNYL DERIVATIVES AS MGLUR5 ALLOSTERIC MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013050454-A1 | ETHYNYL DERIVATIVES AS MGLUR5 ALLOSTERIC MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-04-11 | — | — | WO | disclosed |
| US-20130090332-A1 | ETHYNYL DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2013-04-11 | — | — | US | disclosed |
| US-20130090332-A1 | ETHYNYL DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2013-04-11 | — | — | US | disclosed |
| US-20130090332-A1 | ETHYNYL DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2013-04-11 | — | — | US | disclosed |
| WO-2013050454-A1 | ETHYNYL DERIVATIVES AS MGLUR5 ALLOSTERIC MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-04-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130090332-A1 | ETHYNYL DERIVATIVES | GRM5, GRIK5, GRM1 | AR 931/4885GRM5 1/4885CHRNB2 350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.