Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | KDM6B | O15054 | 7/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14842896 | 0.74 | PDE10A (0.41) | PDE10A | |
| SCHEMBL14554710 | 0.73 | PDE10A (0.53) | PDE10AHDAC6 | |
| SCHEMBL14844871 | 0.71 | PDE10A (0.52) | PDE10A | |
| SCHEMBL14843494 | 0.71 | PDE10A (0.57) | PDE10A | |
| SCHEMBL14843040 | 0.69 | PDE10A (0.44) | PDE10A | |
| SCHEMBL2040808 | 0.69 | PDE10A (1.00) | PDE10A | |
| SCHEMBL2038629 | 0.69 | PDE10A (1.00) | PDE10A | |
| SCHEMBL14843545 | 0.68 | PDE10A (0.56) | PDE10A | |
| SCHEMBL2040867 | 0.68 | PDE10A (1.00) | PDE10A | |
| SCHEMBL14842742 | 0.67 | PDE10A (0.50) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013050527-A1 | QUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITORS | H. LUNDBECK A/S (DK) | 2013-04-11 | — | — | WO | disclosed |
| WO-2013050527-A1 | QUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITORS | H. LUNDBECK A/S (DK) | 2013-04-11 | — | — | WO | disclosed |