Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 17/20 | 0.78 |
| ▸ | PIK3CA | P42336 | 15/20 | 0.67 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14843227 | 0.91 | MTOR (0.67) | MTORPIK3CAPIK3CB | |
| SCHEMBL14843120 | 0.90 | MTOR (0.66) | MTORPIK3CAPIK3CB | |
| SCHEMBL14843207 | 0.90 | MTOR (0.82) | MTORPIK3CA | |
| SCHEMBL14843208 | 0.88 | MTOR (1.00) | MTORPIK3CA | |
| SCHEMBL14843345 | 0.87 | MTOR (0.82) | MTORPIK3CA | |
| SCHEMBL14843113 | 0.86 | MTOR (0.74) | MTORPIK3CA | |
| SCHEMBL14843223 | 0.86 | MTOR (0.81) | MTORPIK3CA | |
| SCHEMBL14843070 | 0.85 | MTOR (0.80) | MTORPIK3CA | |
| SCHEMBL14843458 | 0.85 | MTOR (0.79) | MTORPIK3CA | |
| SCHEMBL14843472 | 0.83 | MTOR (0.62) | MTORPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763985-B1 | {(4-(4-MORPHOLINO-DIHYDROTHIENO[3,4-D]PYRIMIDIN-2-YL)ARYL}UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS | CELLZOME LTD (GB) | 2016-06-22 | — | — | EP | claimed |
| EP-2763985-A1 | MORPHOLINO SUBSTITUTED BICYCLIC PYRIMIDINE UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS | Cellzome Limited (GB) | 2014-08-13 | — | — | EP | claimed |
| WO-2013050508-A1 | MORPHOLINO SUBSTITUTED BICYCLIC PYRIMIDINE UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS | CELLZOME LIMITED (GB) | 2013-04-11 | — | — | WO | claimed |
| EP-2763985-B1 | {(4-(4-MORPHOLINO-DIHYDROTHIENO[3,4-D]PYRIMIDIN-2-YL)ARYL}UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS | CELLZOME LTD (GB) | 2016-06-22 | — | — | EP | disclosed |
| US-9242993-B2 | Morpholino substituted bicyclic pyrimidine urea or carbamate derivatives as mTOR inhibitors | CELLZOME LIMITED (GB) | 2016-01-26 | — | — | US | disclosed |
| US-9242993-B2 | Morpholino substituted bicyclic pyrimidine urea or carbamate derivatives as mTOR inhibitors | CELLZOME LIMITED (GB) | 2016-01-26 | — | — | US | disclosed |
| US-20140288066-A1 | MORPHOLINO SUBSTITUTED BICYCLIC PYRIMIDINE UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS | CELLZOME LIMITED (GB) | 2014-09-25 | — | — | US | disclosed |
| US-20140288066-A1 | MORPHOLINO SUBSTITUTED BICYCLIC PYRIMIDINE UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS | CELLZOME LIMITED (GB) | 2014-09-25 | — | — | US | disclosed |
| EP-2763985-A1 | MORPHOLINO SUBSTITUTED BICYCLIC PYRIMIDINE UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS | Cellzome Limited (GB) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013050508-A1 | MORPHOLINO SUBSTITUTED BICYCLIC PYRIMIDINE UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS | CELLZOME LIMITED (GB) | 2013-04-11 | — | — | WO | disclosed |
| WO-2013050508-A1 | MORPHOLINO SUBSTITUTED BICYCLIC PYRIMIDINE UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS | CELLZOME LIMITED (GB) | 2013-04-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140288066-A1 | MORPHOLINO SUBSTITUTED BICYCLIC PYRIMIDINE UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS | MTOR, RICTOR, CCNT1 | MTOR 1/4885PIK3CA 166/4885PIK3CB 427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.