Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 16/20 | 0.67 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.65 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14843229 | 0.91 | MTOR (0.78) | MTORPIK3CAPIK3CB | |
| SCHEMBL14843121 | 0.90 | MTOR (0.57) | MTORPIK3CAPIK3CB | |
| SCHEMBL14843203 | 0.90 | MTOR (0.71) | MTORPIK3CA | |
| SCHEMBL14843205 | 0.88 | MTOR (0.85) | MTORPIK3CA | |
| SCHEMBL14843343 | 0.87 | MTOR (0.72) | MTORPIK3CA | |
| SCHEMBL14843119 | 0.86 | MTOR (0.64) | MTORPIK3CA | |
| SCHEMBL14843221 | 0.86 | MTOR (0.71) | MTORPIK3CA | |
| SCHEMBL14843071 | 0.85 | MTOR (0.70) | MTORPIK3CA | |
| SCHEMBL14843456 | 0.85 | MTOR (0.69) | MTORPIK3CA | |
| SCHEMBL14843471 | 0.83 | MTOR (0.62) | MTORPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763985-B1 | {(4-(4-MORPHOLINO-DIHYDROTHIENO[3,4-D]PYRIMIDIN-2-YL)ARYL}UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS | CELLZOME LTD (GB) | 2016-06-22 | — | — | EP | claimed |
| EP-2763985-A1 | MORPHOLINO SUBSTITUTED BICYCLIC PYRIMIDINE UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS | Cellzome Limited (GB) | 2014-08-13 | — | — | EP | claimed |
| WO-2013050508-A1 | MORPHOLINO SUBSTITUTED BICYCLIC PYRIMIDINE UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS | CELLZOME LIMITED (GB) | 2013-04-11 | — | — | WO | claimed |
| EP-2763985-A1 | MORPHOLINO SUBSTITUTED BICYCLIC PYRIMIDINE UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS | Cellzome Limited (GB) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013050508-A1 | MORPHOLINO SUBSTITUTED BICYCLIC PYRIMIDINE UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS | CELLZOME LIMITED (GB) | 2013-04-11 | — | — | WO | disclosed |