Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.38 |
| ▸ | TP53 | P04637 | 6/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 8/20 | 0.35 |
| ▸ | FABP5 | Q01469 | 8/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2595283 | 0.83 | SMN1; SMN2 (0.40) | SMN1; SMN2TP53L3MBTL1POLBFABP4 | |
| SCHEMBL2596227 | 0.83 | SMN1; SMN2 (0.35) | SMN1; SMN2TP53L3MBTL1KDM4EPOLB | |
| SCHEMBL15914064 | 0.75 | SMN1; SMN2 (0.39) | SMN1; SMN2TP53L3MBTL1KDM4EPOLB | |
| SCHEMBL14853198 | 0.75 | SMN1; SMN2 (0.39) | SMN1; SMN2TP53L3MBTL1KDM4EPOLB | |
| SCHEMBL3590392 | 0.65 | SMN1; SMN2 (0.50) | SMN1; SMN2TP53L3MBTL1KDM4EPOLB | |
| SCHEMBL2579226 | 0.65 | MAPT (0.39) | SMN1; SMN2TP53L3MBTL1KDM4EPOLB | |
| SCHEMBL2579228 | 0.65 | MAPT (0.39) | SMN1; SMN2TP53L3MBTL1KDM4EPOLB | |
| SCHEMBL2586413 | 0.65 | SMN1; SMN2 (0.40) | SMN1; SMN2TP53L3MBTL1KDM4EPOLB | |
| SCHEMBL2586411 | 0.65 | SMN1; SMN2 (0.40) | SMN1; SMN2TP53L3MBTL1KDM4EPOLB | |
| SCHEMBL23846423 | 0.62 | SMN1; SMN2 (0.50) | SMN1; SMN2TP53L3MBTL1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763997-A1 | CYCLOHEXYL-4H,6H-5-OXA-2,3,10B-TRIAZA-BENZO[E]AZULENES AS V1A ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013050334-A1 | CYCLOHEXYL-4H,6H-5-OXA-2,3,10B-TRIAZA-BENZO[E]AZULENES AS V1A ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-04-11 | — | — | WO | disclosed |