Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.40 |
| ▸ | TP53 | P04637 | 8/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CPT2 | P23786 | 1/20 | 0.35 |
| ▸ | CPT1A | P50416 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14844238 | 0.83 | SMN1; SMN2 (0.38) | SMN1; SMN2TP53THRBNPC1RAB9A | |
| SCHEMBL2596227 | 0.82 | SMN1; SMN2 (0.35) | SMN1; SMN2TP53THRBNPC1RAB9A | |
| SCHEMBL2586411 | 0.77 | SMN1; SMN2 (0.40) | SMN1; SMN2TP53THRBNPC1RAB9A | |
| SCHEMBL2593261 | 0.69 | CPT2 (0.48) | SMN1; SMN2SLC6A2SLC6A4CPT2CPT1A | |
| SCHEMBL2593264 | 0.67 | SLC6A2 (0.41) | SMN1; SMN2SLC6A2SLC6A4BDKRB1L3MBTL1 | |
| SCHEMBL272354 | 0.65 | CHRM2 (0.48) | SMN1; SMN2TP53SLC6A2SLC6A4POLB | |
| SCHEMBL8058857 | 0.65 | CHRM2 (0.48) | SMN1; SMN2TP53SLC6A2SLC6A4POLB | |
| SCHEMBL11514730 | 0.65 | CHRM2 (0.48) | SMN1; SMN2TP53SLC6A2SLC6A4POLB | |
| SCHEMBL13595131 | 0.65 | CHRM2 (0.48) | SMN1; SMN2TP53SLC6A2SLC6A4POLB | |
| SCHEMBL15914064 | 0.65 | SMN1; SMN2 (0.39) | SMN1; SMN2TP53THRBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569319-A1 | HETEROARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-03-20 | — | — | EP | disclosed |
| WO-2011141396-A1 | HETEROARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-11-17 | — | — | WO | disclosed |