Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ethosuximide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.88 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.88 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 10/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.30 |
| ▸ | CYP11A1 | P05108 | 1/20 | 0.30 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethosuximide SCHEMBL118395 | 0.94 | TSHR (1.00) | TSHRNPSR1LMNAKDM4ECYP2C19 | |
| Ethosuximide SCHEMBL34212 | 0.94 | TSHR (1.00) | TSHRNPSR1LMNAKDM4ECYP2C19 | |
| Ethosuximide SCHEMBL20980115 | 0.94 | TSHR (1.00) | TSHRNPSR1LMNAKDM4ECYP2C19 | |
| Ethosuximide SCHEMBL4654769 | 0.94 | TSHR (1.00) | TSHRNPSR1LMNAKDM4ECYP2C19 | |
| Ethosuximide SCHEMBL9074587 | 0.91 | TSHR (0.95) | TSHRNPSR1LMNAKDM4ECYP2C19 | |
| Ethosuximide SCHEMBL7449863 | 0.91 | TSHR (0.95) | TSHRNPSR1LMNAKDM4ECYP2C19 | |
| Ethosuximide SCHEMBL18170124 | 0.86 | TSHR (0.84) | TSHRNPSR1LMNAKDM4ECYP2C19 | |
| Ethosuximide SCHEMBL2320250 | 0.83 | TSHR (0.72) | TSHRNPSR1LMNAKDM4ECYP2C19 | |
| Etidronic Acid SCHEMBL6194395 | 0.79 | TSHR (0.66) | TSHRNPSR1LMNAKDM4ECYP2C19 | |
| SCHEMBL1566072 | 0.77 | TSHR (0.69) | TSHRNPSR1LMNAKDM4ECYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2764038-A1 | CROSSLINKABLE COMPOSITION CROSSLINKABLE BY REAL MICHAEL ADDITION (RMA) REACTION | Nuplex Resins B.V. (NL) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013050623-A1 | CROSSLINKABLE COMPOSITION CROSSLINKABLE BY REAL MICHAEL ADDITION (RMA) REACTION | NUPLEX RESINS B.V. (NL) | 2013-04-11 | — | — | WO | disclosed |