Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ethosuximide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 10/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | CYP11A1 | P05108 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethosuximide SCHEMBL20980115 | 1.00 | TSHR (1.00) | TSHRNPSR1LMNAKDM4ECYP2C19 | |
| Ethosuximide SCHEMBL118395 | 1.00 | TSHR (1.00) | TSHRNPSR1LMNAKDM4ECYP2C19 | |
| Ethosuximide SCHEMBL4654769 | 1.00 | TSHR (1.00) | TSHRNPSR1LMNAKDM4ECYP2C19 | |
| Ethosuximide SCHEMBL26925793 | 0.98 | TSHR (0.95) | TSHRNPSR1LMNAKDM4ECYP2C19 | |
| Ethosuximide SCHEMBL9074587 | 0.98 | TSHR (0.95) | TSHRNPSR1LMNAKDM4ECYP2C19 | |
| Ethosuximide SCHEMBL7449863 | 0.98 | TSHR (0.95) | TSHRNPSR1LMNAKDM4ECYP2C19 | |
| Ethosuximide SCHEMBL14844404 | 0.94 | TSHR (0.88) | TSHRNPSR1LMNAKDM4ECYP2C19 | |
| Ethosuximide SCHEMBL18170124 | 0.92 | TSHR (0.84) | TSHRNPSR1LMNAKDM4ECYP2C19 | |
| Ethosuximide SCHEMBL2320250 | 0.85 | TSHR (0.72) | TSHRNPSR1LMNAKDM4ECYP2C19 | |
| SCHEMBL1566072 | 0.82 | TSHR (0.69) | TSHRNPSR1LMNAKDM4ECYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 16124 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| US-20260137654-A1 | COMPOUNDS AND METHODS FOR TREATING AN EPILEPTIC DISORDER | THE REGENTS OF THE UNIV OF CALIFORNIA (US) | 2026-05-21 | — | — | US | claimed |
| EP-4736841-A1 | A MUCOADHESIVE LAYER FOR BUCCAL ADMINISTRATION OF AN ACTIVE PHARMACEUTICAL INGREDIENT | IQ medical GmbH (DE) | 2026-05-06 | — | — | EP | claimed |
| US-12599581-B2 | Method of treating expressive language deficit in autistic humans | AMS THERAPEUTICS (US) | 2026-04-14 | — | — | US | claimed |
| EP-4603815-B1 | TEMPERATURE ESTIMATION MODEL AND METHOD FOR AN ELECTRICAL GENERATOR | SIEMENS GAMESA RENEWABLE ENERGY AS (DK) | 2026-04-08 | — | — | EP | claimed |
| US-12594388-B2 | Device to deliver a predetermined amount of a substance to a natural orifice of the body | APTARGROUP, INC. (US) | 2026-04-07 | — | — | US | claimed |
| US-12594256-B2 | A19-144, A2-73 and certain anticholinesterase inhibitor compositions and method for anti-seizure therapy | ANAVEX LIFE SCIENCES CORP. (US) | 2026-04-07 | — | — | US | claimed |
| US-20260083706-A1 | 5HT AGONISTS FOR TREATING DISORDERS | UNIV CALIFORNIA (US) | 2026-03-26 | — | — | US | claimed |
| US-20260076971-A1 | METHODS OF TREATING EPILEPSY AND REDUCING THE INCIDENCE OF SEIZURES | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2026-03-19 | — | — | US | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| WO-1985000605-A1 | PROCESS FOR SELECTIVE NITRILE REDUCTION | AMERICAN HOSPITAL SUPPLY CORPORATION (US) | 1985-02-14 | — | — | WO | claimed |
| EP-0104926-A2 | Assay processes and materials therefor | UNILEVER PLC (GB) | 1984-04-04 | — | — | EP | claimed |
| EP-0095665-A1 | Labelled conjugates of ethosuximide, ethosuximide immunogens, antibodies thereto, immunoassay method employing the antibodies and reagent means, test kit and test device for the immunoassay method | MILES LABORATORIES, INC. (US) | 1983-12-07 | — | — | EP | claimed |
| US-4404366-A | ENZYME CLEAVABLE GLYCOSIDIC LINKAGE | MILES LABORATORIES, INC. (US) | 1983-09-13 | — | — | US | claimed |
| US-4378428-A | Method for carrying out non-isotopic immunoassays, labeled analytes and kits for use in such assays | BAKER INSTRUMENTS CORPORATION (US) | 1983-03-29 | — | — | US | claimed |
| EP-0062277-A1 | A method for carrying out non-isotopic immunoassays, labeled analytes and kits for use in such assays | Baker Instruments Corporation (US) | 1982-10-13 | — | — | EP | claimed |
| US-4279992-A | Specific binding assay employing an enzyme-cleavable substrate as label | MILES LABORATORIES, INC. (US) | 1981-07-21 | — | — | US | claimed |
| US-4160818-A | Fluorimetric immunoassay for diphenylhydantoin | TECHNICON INSTRUMENTS CORPORATION (US) | 1979-07-10 | — | — | US | claimed |
| US-4126524-A | REACTION PRODUCT OF SILVER SALT AND PYRROLIDINE-2,5-DIONE OR PYRROLINE-2,5-DIONE | TECHNIC, INC. (US) | 1978-11-21 | — | — | US | claimed |
| US-4121577-A | Method and apparatus for aiding conditioning of an erect spinal column and advantageous muscle control | BINDER TIMOTHY A | 1978-10-24 | — | — | US | claimed |