Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14844721 | 0.75 | ALDH1A1 (0.33) | ALDH1A1RECQLMAPK10PDE10A | |
| SCHEMBL14842554 | 0.73 | PDE10A (0.48) | PDE10A | |
| SCHEMBL12830382 | 0.72 | MAPK10 (0.39) | ALDH1A1RECQLMAPK10PDE10A | |
| SCHEMBL20320623 | 0.72 | KMT2A (0.53) | ALDH1A1MAPK10KMT2ALMNA | |
| SCHEMBL24142314 | 0.71 | MAPK10 (0.42) | MAPK10PDE10A | |
| SCHEMBL14842202 | 0.71 | PDE10A (0.41) | ALDH1A1RECQLPDE10A | |
| SCHEMBL16202022 | 0.70 | GAA (0.48) | ALDH1A1HTTKMT2ALMNA | |
| SCHEMBL25694758 | 0.70 | PDE10A (0.40) | MAPK10PDE10A | |
| SCHEMBL3084534 | 0.69 | HTT (0.42) | HTTMAPK10PDE10A | |
| SCHEMBL19687283 | 0.68 | HTT (0.62) | ALDH1A1HTTKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763533-B1 | TRIAZOLYL PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2021-12-29 | — | — | EP | disclosed |
| EP-2763533-B1 | TRIAZOLYL PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2021-12-29 | — | — | EP | disclosed |
| US-9200001-B2 | Triazolyl PDE10 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-12-01 | — | — | US | disclosed |
| US-9200001-B2 | Triazolyl PDE10 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-12-01 | — | — | US | disclosed |
| US-9200001-B2 | Triazolyl PDE10 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-12-01 | — | — | US | disclosed |
| US-20140249134-A1 | TRIAZOLYL PDE10 INHIBITORS | MERCK SHARP & DOHME LLC | 2014-09-04 | — | — | US | disclosed |
| US-20140249134-A1 | TRIAZOLYL PDE10 INHIBITORS | MERCK SHARP & DOHME LLC | 2014-09-04 | — | — | US | disclosed |
| US-20140249134-A1 | TRIAZOLYL PDE10 INHIBITORS | MERCK SHARP & DOHME LLC | 2014-09-04 | — | — | US | disclosed |
| EP-2763533-A1 | TRIAZOLYL PDE10 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013052526-A1 | TRIAZOLYL PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-04-11 | — | — | WO | disclosed |
| WO-2013052526-A1 | TRIAZOLYL PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-04-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140249134-A1 | TRIAZOLYL PDE10 INHIBITORS | PDE10A, PDE12, PDE4A | ALDH1A1 1263/4885HTT 54/4885RECQL 1597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.