SCHEMBL14845244

SCHEMBL14845244

COc1cnc(-c2nn(Cc3c(Cl)cccc3Cl)c3ccccc23)nc1Nc1ccncc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BUB1 O43683 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL14843303 0.99 BUB1 (0.98) BUB1
SCHEMBL16129328 0.92 BUB1 (0.86) BUB1
SCHEMBL14843675 0.92 BUB1 (1.00) BUB1
SCHEMBL14844920 0.91 BUB1 (0.85) BUB1
SCHEMBL14843804 0.91 BUB1 (1.00) BUB1
SCHEMBL19352651 0.91 BUB1 (0.85) BUB1
SCHEMBL14843277 0.91 BUB1 (0.88) BUB1
SCHEMBL14843487 0.90 BUB1 (1.00) BUB1
SCHEMBL15991417 0.90 BUB1 (0.82) BUB1
SCHEMBL14845254 0.90 BUB1 (0.85) BUB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190284206-A1 SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES BAYER INTELLECTUAL PROPERTY GMBH (DE) 2019-09-19 US claimed
EP-2763982-B1 SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES. Bayer Pharma AG (DE) 2018-01-10 EP claimed
US-20170260198-A1 SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-09-14 US claimed
US-9265763-B2 2016-02-23 US claimed
US-20140249133-A1 SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2014-09-04 US claimed
US-10604532-B2 Substituted benzylindazoles for use as BUB1 kinase inhibitors in the treatment of hyperproliferative diseases BAYER INTELLECTUAL PROPERTY GMBH (DE) 2020-03-31 US disclosed
US-10604532-B2 Substituted benzylindazoles for use as BUB1 kinase inhibitors in the treatment of hyperproliferative diseases BAYER INTELLECTUAL PROPERTY GMBH (DE) 2020-03-31 US disclosed
US-20190284206-A1 SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES BAYER INTELLECTUAL PROPERTY GMBH (DE) 2019-09-19 US disclosed
US-20190284206-A1 SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES BAYER INTELLECTUAL PROPERTY GMBH (DE) 2019-09-19 US disclosed
US-10266548-B2 Substituted benzylindazoles for use as Bub1 kinase inhibitors in the treatment of hyperproliferative diseases BAYER INTELLECTUAL PROPERTY GMBH (DE) 2019-04-23 US disclosed
US-10266548-B2 Substituted benzylindazoles for use as Bub1 kinase inhibitors in the treatment of hyperproliferative diseases BAYER INTELLECTUAL PROPERTY GMBH (DE) 2019-04-23 US disclosed
EP-2763982-B1 SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES. Bayer Pharma AG (DE) 2018-01-10 EP disclosed
US-9265763-B2 2016-02-23 US disclosed
US-9265763-B2 2016-02-23 US disclosed
US-20140249133-A1 SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2014-09-04 US disclosed
US-20140249133-A1 SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2014-09-04 US disclosed
US-20140249133-A1 SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2014-09-04 US disclosed
EP-2763982-A1 SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES. Bayer Pharma Aktiengesellschaft (DE) 2014-08-13 EP disclosed
WO-2013050438-A1 SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES. BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2013-04-11 WO disclosed
WO-2013050438-A1 SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES. BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2013-04-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10604532-B2 Substituted benzylindazoles for use as BUB1 kinase inhibitors in the treatment of hyperproliferative diseases BUB1, BUB1B, BUB3 BUB1 1/4885
US-20140249133-A1 SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES BUB1, BUB1B, BUB3 BUB1 1/4885
US-20170260198-A1 SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES BUB1, BUB1B, BUB3 BUB1 1/4885
US-20190284206-A1 SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES BUB1, BUB1B, BUB3 BUB1 1/4885
US-10266548-B2 Substituted benzylindazoles for use as Bub1 kinase inhibitors in the treatment of hyperproliferative diseases BUB1, BUB1B, BUB3 BUB1 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.