Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 19/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | SCD | O00767 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2518871 | 0.94 | GPR119 (0.83) | GPR119KCNH2 | |
| SCHEMBL12213566 | 0.91 | GPR119 (0.88) | GPR119KCNH2SCD | |
| SCHEMBL2524106 | 0.91 | GPR119 (0.84) | GPR119KCNH2SCD | |
| SCHEMBL12213563 | 0.89 | GPR119 (0.77) | GPR119KCNH2SCD | |
| SCHEMBL14845358 | 0.88 | GPR119 (0.75) | GPR119KCNH2SCD | |
| SCHEMBL12213571 | 0.88 | GPR119 (0.75) | GPR119KCNH2SCD | |
| SCHEMBL2517681 | 0.85 | GPR119 (1.00) | GPR119KCNH2 | |
| SCHEMBL2333267 | 0.84 | GPR119 (1.00) | GPR119KCNH2 | |
| SCHEMBL2333321 | 0.83 | GPR119 (0.86) | GPR119KCNH2 | |
| SCHEMBL12213570 | 0.82 | GPR119 (0.89) | GPR119KCNH2SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8415367-B2 | Pyrimidinylpiperidinyloxypyridinone analogues as GPR119 modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-04-09 | — | — | US | disclosed |