Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TNNI3K | Q59H18 | 4/20 | 0.49 |
| ▸ | IKBKB | O14920 | 4/20 | 0.45 |
| ▸ | CHUK | O15111 | 4/20 | 0.45 |
| ▸ | NEK1 | Q96PY6 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.40 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.40 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14620965 | 0.86 | TNNI3K (0.47) | TNNI3KIKBKBCHUKNEK1ROCK1 | |
| SCHEMBL857853 | 0.85 | NEK1 (0.53) | KMT2AIKBKBCHUKNEK1ALDH1A1 | |
| SCHEMBL857664 | 0.85 | ROCK1 (0.48) | TNNI3KIKBKBCHUKALDH1A1ROCK1 | |
| SCHEMBL13116651 | 0.85 | NEK1 (0.52) | TNNI3KIKBKBCHUKNEK1ROCK1 | |
| SCHEMBL14845848 | 0.84 | KMT2A (0.50) | KMT2AALDH1A1ROCK1MEN1SLC40A1 | |
| SCHEMBL857944 | 0.83 | GPBAR1 (0.46) | KMT2ATNNI3KIKBKBCHUKBRAF | |
| SCHEMBL857237 | 0.82 | L3MBTL1 (0.58) | KMT2ATNNI3KALDH1A1MEN1 | |
| SCHEMBL14620964 | 0.82 | L3MBTL1 (0.45) | KMT2ATNNI3KIKBKBCHUKNEK1 | |
| SCHEMBL857108 | 0.80 | IKBKB (0.48) | KMT2ATNNI3KIKBKBCHUKNEK1 | |
| SCHEMBL858357 | 0.80 | NEK1 (0.46) | TNNI3KIKBKBCHUKNEK1ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8415469-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2013-04-09 | — | — | US | disclosed |