Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8264510 | 0.80 | ALDH1A1 (0.56) | KDM4ETDP1ALDH1A1KMT2AMAPK1 | |
| SCHEMBL19367987 | 0.79 | ALDH1A1 (0.59) | KDM4ETDP1ALDH1A1KMT2AMEN1 | |
| SCHEMBL17724132 | 0.76 | CYP2A13 (0.71) | KDM4EALDH1A1KMT2AMEN1HSD17B10 | |
| SCHEMBL13779315 | 0.75 | KMT2A (0.69) | KDM4EALDH1A1KMT2AMEN1TSHR | |
| SCHEMBL16174053 | 0.74 | ALDH1A1 (0.57) | KDM4ETDP1ALDH1A1KMT2AMEN1 | |
| SCHEMBL4252553 | 0.73 | NPC1 (0.48) | KDM4ETDP1ALDH1A1KMT2AMEN1 | |
| SCHEMBL14417408 | 0.73 | NPC1 (0.50) | KDM4ETDP1ALDH1A1KMT2AMEN1 | |
| SCHEMBL402703 | 0.72 | SMN1; SMN2 (0.49) | KDM4EALDH1A1KMT2AMEN1HTT | |
| SCHEMBL17152792 | 0.71 | ALDH1A1 (0.44) | KDM4ETDP1ALDH1A1KMT2AMEN1 | |
| SCHEMBL13779322 | 0.71 | KDM4E (0.58) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1959960-B1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS INC (US) | 2013-04-10 | — | — | EP | disclosed |