Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.82 |
| ▸ | PRKACG | P22612 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9910180 | 1.00 | MET (0.82) | METCYP3A4PRKACG | |
| SCHEMBL9910179 | 1.00 | MET (0.82) | METCYP3A4PRKACG | |
| SCHEMBL9910174 | 0.90 | MET (1.00) | METCYP3A4PRKACG | |
| SCHEMBL9910175 | 0.90 | MET (1.00) | METCYP3A4PRKACG | |
| SCHEMBL14848275 | 0.90 | MET (1.00) | METCYP3A4PRKACG | |
| Amg-208 SCHEMBL9910136 | 0.82 | MET (1.00) | METCYP3A4PRKACG | |
| Amg-208 SCHEMBL30274835 | 0.82 | MET (1.00) | METCYP3A4PRKACG | |
| SCHEMBL9910185 | 0.78 | MET (0.74) | METCYP3A4PRKACG | |
| SCHEMBL9910186 | 0.78 | MET (0.74) | METCYP3A4PRKACG | |
| SCHEMBL18231529 | 0.78 | MET (0.74) | METCYP3A4PRKACG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2578583-A1 | Fused heterocyclic derivatives and methods of use | Amgen Inc. (US) | 2013-04-10 | — | — | EP | disclosed |