Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 11/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL247990 | 0.91 | PIK3CA (0.48) | PIK3CAPIK3CDMAPK14KDM4E | |
| SCHEMBL248725 | 0.88 | PIK3CA (0.50) | PIK3CAPIK3CD | |
| SCHEMBL245762 | 0.88 | PIK3CA (0.43) | PIK3CAPIK3CDKDM4E | |
| SCHEMBL245594 | 0.87 | PIK3CA (0.52) | PIK3CAPIK3CD | |
| SCHEMBL247290 | 0.87 | PIK3CA (0.52) | PIK3CAPIK3CD | |
| SCHEMBL252079 | 0.87 | PIK3CA (0.43) | PIK3CAPIK3CDKDM4E | |
| SCHEMBL248133 | 0.87 | PIK3CA (0.43) | PIK3CAPIK3CDKDM4E | |
| SCHEMBL248229 | 0.86 | PIK3CA (0.51) | PIK3CAPIK3CD | |
| SCHEMBL248486 | 0.84 | PIK3CA (0.53) | PIK3CAPIK3CD | |
| SCHEMBL248279 | 0.81 | PIK3CD (0.63) | PIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130090323-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2013-04-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130090323-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, MALT1, BCL9 | PIK3CA 28/4885PIK3CD 24/4885PDE10A 3392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.