Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | KIF18A | Q8NI77 | 3/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | STK3 | Q13188 | 1/20 | 0.36 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL248133 | 1.00 | PIK3CA (0.43) | PIK3CAPIK3CDKIF18AIRAK4CLK2 | |
| SCHEMBL245762 | 0.92 | PIK3CA (0.43) | PIK3CAPIK3CDKIF18AIRAK4CLK2 | |
| SCHEMBL247290 | 0.91 | PIK3CA (0.52) | PIK3CAPIK3CDKIF18AIRAK4CLK2 | |
| SCHEMBL248486 | 0.88 | PIK3CA (0.53) | PIK3CAPIK3CDKIF18ACLK2GSK3A | |
| SCHEMBL14849005 | 0.87 | PIK3CA (0.49) | PIK3CAPIK3CDKDM4E | |
| SCHEMBL248725 | 0.85 | PIK3CA (0.50) | PIK3CAPIK3CDKIF18APIK3CBMTOR | |
| SCHEMBL247990 | 0.85 | PIK3CA (0.48) | PIK3CAPIK3CDKDM4E | |
| SCHEMBL2710884 | 0.81 | PIK3CA (0.49) | PIK3CAPIK3CD | |
| SCHEMBL248229 | 0.81 | PIK3CA (0.51) | PIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL245594 | 0.80 | PIK3CA (0.52) | PIK3CAPIK3CDMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588471-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003283-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |