Tolperisone

Tolperisone

SCHEMBL148499

Cc1ccc(C(=O)C(C)CN2CCCCC2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 2/20 1.00
ADRA2B P18089 2/20 1.00
DRD3 P35462 2/20 1.00
SIGMAR1 Q99720 2/20 1.00
HRH3 Q9Y5N1 2/20 1.00
ALDH1A1 P00352 4/20 0.97
LMNA P02545 3/20 0.97
CYP2D6 P10635 1/20 0.74
ADRA2C P18825 1/20 0.74
CHRM3 P20309 1/20 0.74
OPRD1 P41143 1/20 0.74
KCNH2 Q12809 1/20 0.74
SLC6A4 P31645 4/20 0.63
SLC6A3 Q01959 6/20 0.55
SLC6A2 P23975 5/20 0.55
NTSR1 P30989 1/20 0.49
MITF O75030 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
HTT P42858 1/20 0.49
RAB9A P51151 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21451092 1.00 CHRM2 (1.00) CHRM2ADRA2BDRD3SIGMAR1HRH3
Tolperisone SCHEMBL17223884 1.00 CHRM2 (1.00) CHRM2ADRA2BDRD3SIGMAR1HRH3
Tolperisone SCHEMBL4516510 1.00 CHRM2 (1.00) CHRM2ADRA2BDRD3SIGMAR1HRH3
Tolperisone SCHEMBL4780118 1.00 CHRM2 (1.00) CHRM2ADRA2BDRD3SIGMAR1HRH3
Tolperisone SCHEMBL872770 0.98 ALDH1A1 (1.00) CHRM2ADRA2BDRD3SIGMAR1HRH3
SCHEMBL9172663 0.98 CHRM2 (0.97) CHRM2ADRA2BDRD3SIGMAR1HRH3
Tolperisone SCHEMBL15663055 0.97 CHRM2 (0.94) CHRM2ADRA2BDRD3SIGMAR1HRH3
Deutolperisone SCHEMBL5371621 0.90 CHRM2 (0.81) CHRM2ADRA2BDRD3SIGMAR1HRH3
Tolperisone SCHEMBL5356342 0.90 CHRM2 (0.81) CHRM2ADRA2BDRD3SIGMAR1HRH3
SCHEMBL10852535 0.88 CHRM2 (0.78) CHRM2ADRA2BDRD3SIGMAR1HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2910 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120121747-A Method for simultaneously measuring tolperisone hydrochloride, methyl hesperidin and vitamin B6 content in Naoluotong capsule 浙江省食品药品检验研究院(《中国现代应用药学》杂志社) 2025-06-10 CN claimed
CN-120079360-A Oily sewage adsorbent and preparation method and application thereof 中国石油化工股份有限公司 2025-06-03 CN claimed
WO-2025111482-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS BEXSON BIOMEDICAL, INC. (US) 2025-05-30 WO claimed
CN-119241531-B Synthesis process of 6-hydroxy tropinone 湖州恒远生物化学技术有限公司 2025-05-06 CN claimed
US-12292363-B2 Method for preparing biological material having excellent light-transmitting property RIKEN (JP) 2025-05-06 US claimed
WO-2025062440-A1 TOPICAL NANO-DISPERSION COMPOSITIONS AND THEIR PREPARATION THEREOF PULSE PHARMACEUTICALS PVT. LTD (IN) 2025-03-27 WO claimed
CN-119488493-A Naoluotong capsule and preparation method thereof 一力制药(罗定)有限公司 2025-02-21 CN claimed
CN-119241531-A Synthesis process of 6-hydroxy tropinone 湖州恒远生物化学技术有限公司 2025-01-03 CN claimed
US-20240374769-A1 LIGHT ACTIVATED CLEANING COMPOSITION THE PROCTER & GAMBLE COMPANY 2024-11-14 US claimed
WO-2024233595-A1 LIGHT ACTIVATED CLEANING COMPOSITION THE PROCTER & GAMBLE COMPANY (US) 2024-11-14 WO claimed
EP-0580860-B1 METHOD OF MANUFACTURING SOLID DISPERSION NIPPON SHINYAKU CO LTD (JP) 1997-10-22 EP claimed
EP-0273375-B2 Propiophenone derivatives for treatment of pollakiuria (frequency urination) HOKURIKU PHARMACEUTICAL (JP) 1995-05-10 EP claimed
EP-0454089-B1 Percutaneously absorbable eperisone or tolperisone preparation SEIKISUI CHEMICAL CO LTD (JP) 1994-08-17 EP claimed
US-5252588-A Percutaneously absorbable crosslinked polyvinylpyrrolidone eperisone or tolperisone preparation SEKISUI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1993-10-12 US claimed
US-5073375-A Monoglyceride or lactic acid ester SANSHO CO., LTD. (JP) 1991-12-17 US claimed
EP-0454089-A1 Percutaneously absorbable eperisone or tolperisone preparation SEKISUI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1991-10-30 EP claimed
US-5059427-A PHARMACEUTICAL PREPARATION FOR PERCUTANEOUS ADMINISTRATION CONTAINING EPERISONE OR TOLPERISONE OR SALT THEREOF SANSHO CO., LTD. (JP) 1991-10-22 US claimed
EP-0295411-B1 PHARMACEUTICAL PREPARATION FOR PERCUTANEOUS ADMINISTRATION CONTAINING EPERISONE OR TOLPERISONE OR A SALT THEREOF Sansho Co., Ltd. (JP) 1990-09-05 EP claimed
US-4912116-A Propiophenone derivatives for treatment of pollakiuria (frequency urination) HOKURIKU PHARMACEUTICAL CO., LTD. (JP) 1990-03-27 US claimed
EP-0295411-A1 Pharmaceutical preparation for percutaneous administration containing eperisone or tolperisone or a salt thereof Sansho Co., Ltd. (JP) 1988-12-21 EP claimed