Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 9/20 | 0.55 |
| ▸ | CASP7 | P55210 | 6/20 | 0.55 |
| ▸ | CASP1 | P29466 | 5/20 | 0.55 |
| ▸ | CASP9 | P55211 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CASP4 | P49662 | 3/20 | 0.46 |
| ▸ | CASP10 | Q92851 | 3/20 | 0.46 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.46 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5888314 | 0.90 | MEN1 (0.54) | CASP3CASP7CASP1CASP9MEN1 | |
| SCHEMBL29419657 | 0.90 | SIRT5 (0.54) | CASP3MEN1KMT2ATDP1KDM4E | |
| SCHEMBL29742197 | 0.90 | SIRT5 (0.54) | CASP3MEN1KMT2ATDP1KDM4E | |
| SCHEMBL15569405 | 0.90 | SIRT5 (0.54) | CASP3MEN1KMT2ATDP1KDM4E | |
| SCHEMBL29419659 | 0.90 | SIRT5 (0.54) | CASP3MEN1KMT2ATDP1KDM4E | |
| SCHEMBL29445883 | 0.87 | KDM4E (0.53) | CASP3MEN1KMT2ATDP1KDM4E | |
| SCHEMBL1552674 | 0.87 | KDM4E (0.53) | CASP3MEN1KMT2ATDP1KDM4E | |
| SCHEMBL29791072 | 0.87 | KDM4E (0.50) | MEN1KMT2ATDP1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL8357861 | 0.86 | KDM4E (0.49) | MEN1KMT2ATDP1KDM4EALDH1A1 | |
| SCHEMBL29470083 | 0.86 | KDM4E (0.52) | MEN1KMT2ATDP1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130280269-A1 | Manipulation of HSP70 and IRE1Alpha Protein Interactions | NATIONAL UNIVERSITY OF IRELAND (IE) | 2013-10-24 | — | — | US | disclosed |
| EP-2580232-A1 | MANIPULATION OF HSP70 AND IRE1ALPHA PROTEIN INTERACTIONS | National University of Ireland, Galway (IE) | 2013-04-17 | — | — | EP | disclosed |
| WO-2011154908-A1 | MANIPULATION OF HSP70 AND IRE1ALPHA PROTEIN INTERACTIONS | NATIONAL UNIVERSITY OF IRELAND, GALWAY (IE) | 2011-12-15 | — | — | WO | disclosed |