SCHEMBL14856830

SCHEMBL14856830

CC(O)(CNC(=O)Oc1nc(-c2ccc(Cl)cc2)c(OCC2CC2)nc1C(F)(F)F)C1CC1

nearest known ligand 0.56

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 12/20 0.56
CNR2 P34972 12/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14856872 0.91 CNR1 (0.45) CNR1CNR2
SCHEMBL14856845 0.91 CNR1 (0.49) CNR1CNR2
SCHEMBL14856810 0.90 CNR1 (0.49) CNR1CNR2
SCHEMBL14856733 0.88 CNR1 (0.43) CNR1CNR2
SCHEMBL10031414 0.87 CNR1 (0.61) CNR1CNR2
SCHEMBL212570 0.87 CNR1 (0.61) CNR1CNR2
SCHEMBL10031418 0.87 CNR1 (0.61) CNR1CNR2
SCHEMBL14856797 0.82 CNR1 (0.40) CNR1CNR2
SCHEMBL14856856 0.82 CNR1 (0.39) CNR1CNR2
SCHEMBL14856883 0.79 GPR119 (0.35) CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2271632-B1 3-TRIFLUOROMETHYL-PYRAZINE-2-CARBOXYLIC ACID AMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS HOFFMANN LA ROCHE (CH) 2013-04-17 EP claimed