Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 9/20 | 1.00 |
| ▸ | IGF1R | P08069 | 2/20 | 0.75 |
| ▸ | MEN1 | O00255 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | HPGD | P15428 | 1/20 | 0.71 |
| ▸ | RECQL | P46063 | 1/20 | 0.71 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.67 |
| ▸ | PNP | P00491 | 1/20 | 0.58 |
| ▸ | GSK3B | P49841 | 2/20 | 0.56 |
| ▸ | PIM1 | P11309 | 2/20 | 0.56 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.56 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.56 |
| ▸ | CDC7 | O00311 | 1/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.56 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8182124 | 1.00 | TDP1 (1.00) | TDP1IGF1RMEN1MAPTKMT2A | |
| SCHEMBL8182123 | 1.00 | TDP1 (1.00) | TDP1IGF1RMEN1MAPTKMT2A | |
| SCHEMBL1249176 | 0.86 | IGF1R (1.00) | TDP1IGF1RMEN1MAPTKMT2A | |
| SCHEMBL15421448 | 0.86 | IGF1R (1.00) | TDP1IGF1RMEN1MAPTKMT2A | |
| SCHEMBL1249172 | 0.86 | IGF1R (1.00) | TDP1IGF1RMEN1MAPTKMT2A | |
| SCHEMBL14860914 | 0.85 | TDP1 (1.00) | TDP1IGF1RMEN1MAPTKMT2A | |
| SCHEMBL14860909 | 0.85 | TDP1 (1.00) | TDP1IGF1RMEN1MAPTKMT2A | |
| SCHEMBL14860913 | 0.85 | TDP1 (1.00) | TDP1IGF1RMEN1MAPTKMT2A | |
| SCHEMBL8172875 | 0.81 | TDP1 (0.68) | TDP1MEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL8172873 | 0.81 | TDP1 (0.68) | TDP1MEN1MAPTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013055771-A1 | THIOXOTHIAZOLIDINONE DERIVATIVES USEFUL AS INHIBITORS OF TDP1 | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2013-04-18 | — | — | WO | disclosed |