Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 7/20 | 1.00 |
| ▸ | PIM1 | P11309 | 4/20 | 0.79 |
| ▸ | PIM3 | Q86V86 | 4/20 | 0.79 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.79 |
| ▸ | GSK3B | P49841 | 3/20 | 0.79 |
| ▸ | CDC7 | O00311 | 2/20 | 0.79 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.79 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.79 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.79 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.79 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.79 |
| ▸ | CLK2 | P49760 | 2/20 | 0.79 |
| ▸ | GSK3A | P49840 | 2/20 | 0.79 |
| ▸ | NEK4 | P51957 | 2/20 | 0.79 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.79 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.79 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.79 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.79 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.79 |
| ▸ | BRSK1 | Q8TDC3 | 2/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14860909 | 1.00 | TDP1 (1.00) | TDP1PIM1PIM3PIM2GSK3B | |
| SCHEMBL14860914 | 1.00 | TDP1 (1.00) | TDP1PIM1PIM3PIM2GSK3B | |
| SCHEMBL1248757 | 0.88 | PIM1 (1.00) | TDP1PIM1PIM3PIM2GSK3B | |
| SCHEMBL1248758 | 0.88 | PIM1 (1.00) | TDP1PIM1PIM3PIM2GSK3B | |
| SCHEMBL15421409 | 0.88 | PIM1 (1.00) | TDP1PIM1PIM3PIM2GSK3B | |
| SCHEMBL14860898 | 0.85 | TDP1 (1.00) | TDP1PIM1PIM3PIM2GSK3B | |
| SCHEMBL8182124 | 0.85 | TDP1 (1.00) | TDP1PIM1PIM3PIM2GSK3B | |
| SCHEMBL8182123 | 0.85 | TDP1 (1.00) | TDP1PIM1PIM3PIM2GSK3B | |
| SCHEMBL14860883 | 0.84 | TDP1 (1.00) | TDP1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL14860886 | 0.84 | TDP1 (1.00) | TDP1MEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013055771-A1 | THIOXOTHIAZOLIDINONE DERIVATIVES USEFUL AS INHIBITORS OF TDP1 | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2013-04-18 | — | — | WO | disclosed |