Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 16/20 | 1.00 |
| ▸ | NAT1 | P18440 | 2/20 | 0.72 |
| ▸ | TDP2 | O95551 | 1/20 | 0.67 |
| ▸ | PNP | P00491 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14860912 | 1.00 | TDP1 (1.00) | TDP1NAT1TDP2PNPMEN1 | |
| SCHEMBL14860908 | 1.00 | TDP1 (1.00) | TDP1NAT1TDP2PNPMEN1 | |
| SCHEMBL14860947 | 0.88 | TDP1 (1.00) | TDP1NAT1TDP2PNP | |
| SCHEMBL14860944 | 0.88 | TDP1 (1.00) | TDP1NAT1TDP2PNP | |
| SCHEMBL14860946 | 0.88 | TDP1 (1.00) | TDP1NAT1TDP2PNP | |
| SCHEMBL1249158 | 0.84 | NAT1 (1.00) | TDP1NAT1TDP2MEN1ALDH1A1 | |
| SCHEMBL7985096 | 0.84 | NAT1 (1.00) | TDP1NAT1TDP2MEN1ALDH1A1 | |
| SCHEMBL1249157 | 0.84 | NAT1 (1.00) | TDP1NAT1TDP2MEN1ALDH1A1 | |
| SCHEMBL14564270 | 0.84 | NAT1 (1.00) | TDP1NAT1TDP2MEN1ALDH1A1 | |
| SCHEMBL7813222 | 0.84 | NAT1 (1.00) | TDP1NAT1TDP2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013055771-A1 | THIOXOTHIAZOLIDINONE DERIVATIVES USEFUL AS INHIBITORS OF TDP1 | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2013-04-18 | — | — | WO | disclosed |