Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 16/20 | 1.00 |
| ▸ | PIM1 | P11309 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.55 |
| ▸ | AHR | P35869 | 1/20 | 0.53 |
| ▸ | TDP2 | O95551 | 1/20 | 0.50 |
| ▸ | PNP | P00491 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14860982 | 1.00 | TDP1 (1.00) | TDP1PIM1MEN1ALDH1A1MAPT | |
| SCHEMBL14860983 | 1.00 | TDP1 (1.00) | TDP1PIM1MEN1ALDH1A1MAPT | |
| SCHEMBL23579371 | 0.86 | PIM1 (0.75) | TDP1PIM1MEN1ALDH1A1MAPT | |
| SCHEMBL23579374 | 0.86 | PIM1 (0.75) | TDP1PIM1MEN1ALDH1A1MAPT | |
| SCHEMBL23578866 | 0.81 | PIM1 (1.00) | TDP1PIM1MEN1ALDH1A1MAPT | |
| SCHEMBL23578868 | 0.81 | PIM1 (1.00) | TDP1PIM1MEN1ALDH1A1MAPT | |
| SCHEMBL8187020 | 0.75 | TDP1 (0.60) | TDP1MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL8187019 | 0.75 | TDP1 (0.60) | TDP1MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL2685789 | 0.74 | TDP1 (0.70) | TDP1PIM1PNP | |
| SCHEMBL2685792 | 0.74 | TDP1 (0.70) | TDP1PIM1PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013055771-A1 | THIOXOTHIAZOLIDINONE DERIVATIVES USEFUL AS INHIBITORS OF TDP1 | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2013-04-18 | — | — | WO | disclosed |