Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 18/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | TTR | P02766 | 1/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.51 |
| ▸ | TDP2 | O95551 | 1/20 | 0.50 |
| ▸ | PNP | P00491 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8187020 | 1.00 | TDP1 (0.60) | TDP1MEN1KMT2AALDH1A1GAA | |
| SCHEMBL15101827 | 0.86 | TTR (0.69) | TDP1MEN1KMT2AGAAMAPT | |
| SCHEMBL8173296 | 0.86 | PIM1 (0.51) | TDP1MEN1KMT2AALDH1A1GAA | |
| SCHEMBL8173297 | 0.86 | PIM1 (0.51) | TDP1MEN1KMT2AALDH1A1GAA | |
| SCHEMBL14226362 | 0.81 | PIM1 (0.71) | MEN1KMT2AALDH1A1MAPTMAPK1 | |
| SCHEMBL14860998 | 0.77 | TDP1 (0.68) | TDP1MEN1KMT2AALDH1A1GAA | |
| SCHEMBL14861001 | 0.77 | TDP1 (0.68) | TDP1MEN1KMT2AALDH1A1GAA | |
| SCHEMBL14861000 | 0.77 | TDP1 (0.68) | TDP1MEN1KMT2AALDH1A1GAA | |
| SCHEMBL14860983 | 0.75 | TDP1 (1.00) | TDP1MEN1KMT2AALDH1A1GAA | |
| SCHEMBL14860985 | 0.75 | TDP1 (1.00) | TDP1MEN1KMT2AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018746-A1 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |