Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 13/20 | 1.00 |
| ▸ | CISD1 | Q9NZ45 | 4/20 | 0.70 |
| ▸ | MAOA | P21397 | 2/20 | 0.70 |
| ▸ | GSK3B | P49841 | 1/20 | 0.70 |
| ▸ | PNP | P00491 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14860989 | 1.00 | TDP1 (1.00) | TDP1CISD1MAOAGSK3BPNP | |
| SCHEMBL14860991 | 1.00 | TDP1 (1.00) | TDP1CISD1MAOAGSK3BPNP | |
| SCHEMBL14860976 | 0.83 | TDP1 (1.00) | TDP1GSK3BPNPMEN1ALDH1A1 | |
| SCHEMBL14860974 | 0.83 | TDP1 (1.00) | TDP1GSK3BPNPMEN1ALDH1A1 | |
| SCHEMBL14860978 | 0.83 | TDP1 (1.00) | TDP1GSK3BPNPMEN1ALDH1A1 | |
| SCHEMBL1249998 | 0.82 | CISD1 (1.00) | TDP1CISD1MAOAGSK3BHPGD | |
| SCHEMBL2424616 | 0.82 | CISD1 (1.00) | TDP1CISD1MAOAGSK3BHPGD | |
| SCHEMBL19546477 | 0.82 | TDP1 (0.70) | TDP1PNP | |
| SCHEMBL2685789 | 0.82 | TDP1 (0.70) | TDP1PNP | |
| SCHEMBL2685792 | 0.82 | TDP1 (0.70) | TDP1PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013055771-A1 | THIOXOTHIAZOLIDINONE DERIVATIVES USEFUL AS INHIBITORS OF TDP1 | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2013-04-18 | — | — | WO | disclosed |