Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 12/20 | 1.00 |
| ▸ | GSK3B | P49841 | 1/20 | 0.74 |
| ▸ | PNP | P00491 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14860978 | 1.00 | TDP1 (1.00) | TDP1GSK3BPNPGAAL3MBTL1 | |
| SCHEMBL14860974 | 1.00 | TDP1 (1.00) | TDP1GSK3BPNPGAAL3MBTL1 | |
| SCHEMBL23094695 | 0.85 | GSK3B (1.00) | TDP1GSK3BGAAL3MBTL1HTT | |
| SCHEMBL14860991 | 0.83 | TDP1 (1.00) | TDP1GSK3BPNPLMNAMEN1 | |
| SCHEMBL14860989 | 0.83 | TDP1 (1.00) | TDP1GSK3BPNPLMNAMEN1 | |
| SCHEMBL14860992 | 0.83 | TDP1 (1.00) | TDP1GSK3BPNPLMNAMEN1 | |
| SCHEMBL19546477 | 0.82 | TDP1 (0.70) | TDP1PNP | |
| SCHEMBL2685792 | 0.82 | TDP1 (0.70) | TDP1PNP | |
| SCHEMBL2685789 | 0.82 | TDP1 (0.70) | TDP1PNP | |
| SCHEMBL8307311 | 0.79 | GSK3B (0.74) | TDP1GSK3BGAAL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013055771-A1 | THIOXOTHIAZOLIDINONE DERIVATIVES USEFUL AS INHIBITORS OF TDP1 | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2013-04-18 | — | — | WO | disclosed |