Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 2/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.32 |
| ▸ | BTK | Q06187 | 4/20 | 0.31 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TTR | P02766 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL732963 | 0.93 | CETP (0.35) | CETPTBXA2RPTGDRPTGDR2PSEN1 | |
| SCHEMBL700509 | 0.92 | CNR1 (0.35) | TBXA2RPTGDRPTGDR2TACR1GPBAR1 | |
| SCHEMBL701811 | 0.92 | TRPM2 (0.39) | TBXA2RPTGDRPTGDR2PSEN1PSEN2 | |
| SCHEMBL701303 | 0.92 | TRPM2 (0.39) | TBXA2RPTGDRPTGDR2PSEN1PSEN2 | |
| SCHEMBL700510 | 0.92 | CNR1 (0.35) | TBXA2RPTGDRPTGDR2TACR1GPBAR1 | |
| SCHEMBL700781 | 0.91 | PTGDR2 (0.38) | TBXA2RPTGDRPTGDR2PSEN1PSEN2 | |
| SCHEMBL700780 | 0.91 | PTGDR2 (0.38) | TBXA2RPTGDRPTGDR2PSEN1PSEN2 | |
| SCHEMBL701471 | 0.87 | HTR2A (0.33) | CETPTBXA2RPTGDRPTGDR2GPBAR1 | |
| SCHEMBL701470 | 0.87 | HTR2A (0.33) | CETPTBXA2RPTGDRPTGDR2GPBAR1 | |
| SCHEMBL700527 | 0.87 | TRPM2 (0.41) | TBXA2RPTGDRPTGDR2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420675-B2 | Aminotetrahydroindazoloacetic acids | HOFFMANN-LA ROCHE INC. (US) | 2013-04-16 | — | — | US | disclosed |