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TRPM2

Transient receptor potential cation channel subfamily M member 2 · O94759 · TRPM2 on Sugi Atlas →

16,910 patent compounds predicted against TRPM2, 13,887 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL420925 SCHEMBL420925 0.74 5/20
SCHEMBL420926 SCHEMBL420926 0.74 5/20
SCHEMBL417073 SCHEMBL417073 0.61 5/20
SCHEMBL417074 SCHEMBL417074 0.61 5/20
SCHEMBL110009 SCHEMBL110009 0.60 5/20
SCHEMBL1097330 SCHEMBL1097330 0.53 5/20
SCHEMBL1097331 SCHEMBL1097331 0.53 5/20
SCHEMBL957026 SCHEMBL957026 0.52 5/20
SCHEMBL1096847 SCHEMBL1096847 0.52 5/20
SCHEMBL1098546 SCHEMBL1098546 0.49 5/20
SCHEMBL110012 SCHEMBL110012 0.67 4/20
SCHEMBL111339 SCHEMBL111339 0.65 4/20
SCHEMBL418156 SCHEMBL418156 0.59 4/20
SCHEMBL418157 SCHEMBL418157 0.59 4/20
Sulfuric Acid Sulfuric Acid (SCHEMBL957025) 0.57 4/20
Sulfuric Acid Sulfuric Acid (SCHEMBL957027) 0.57 4/20
SCHEMBL110022 SCHEMBL110022 0.53 4/20
SCHEMBL294402 SCHEMBL294402 0.83 3/20
SCHEMBL294403 SCHEMBL294403 0.83 3/20
SCHEMBL110044 SCHEMBL110044 0.69 3/20

Clinical trials — most relevant to TRPM2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Symptom Response in Normal and Dry Eye Patients Secondary to Application of a Menthol-Containing Eyedrop (Rohto® Hydra) PHASE4COMPLETED
Mechanisms of Capsaicin Treatment in Idiopathic Rhinitis Patients and Controls PHASE4COMPLETED
Oliceridine vs Sufentanil for Cough During Anesthesia Induction PHASE4NOT_YET_RECRUITING
The RECONSTRUCT Study - Reconstructing Disease Mechanisms in Asthma PHASE4COMPLETED
The Re-Prosper HF Study PHASE2/PHASE3COMPLETED
TRPM8 Activators for Peripheral Neuropathy PHASE2ACTIVE_NOT_RECRUITING
Early Study on Tamoxifen Safety/Tolerability in Cystic Fibrosis Patients Unable to Use CFTR Modulators. PHASE2NOT_YET_RECRUITING
Calcium Channel Blockade in Primary Aldosteronism PHASE2COMPLETED
Study Designed to Evaluate Safety and Efficacy of 1% Topical Formulation of KM-001 on Type 1 Punctate Palmoplantar Keratoderma or Pachyonychia Congenita Diseases PHASE1COMPLETED
Assessment of KM-001 - Safety, Tolerability, and Efficacy in Patients With PPPK1 or PC PHASE1COMPLETED
Do Acid Sensing Ion Channels Contribute to Heartburn? PHASE1COMPLETED
Mechanism of Human Cold Pain Perception - Involvement of TRPA1, TRPM8, Nav1.7 and Nav1.8 EARLY_PHASE1COMPLETED
Mechanisms of Human Heat Perception - Involvement of TRPA1, TRPV1 and TRPM3 EARLY_PHASE1COMPLETED
Menthol Stimulation of Brown Adipose Tissue in Humans: Aim 1 EARLY_PHASE1RECRUITING
TRPM2 Gene Polymorphism, NLRP3 Inflammasome Expression in Vitiligo Patients nanACTIVE_NOT_RECRUITING
Factors Affecting Salt Intake in Young Adults nanUNKNOWN
Characterization of New Human Models of Non-histaminergic Itch and Their Interaction With the TRPM8 Receptor nanCOMPLETED
Identification of TRP Channels as New Potential Therapeutic Targets in Primary and Secondary Raynaud's Phenomenon. nanCOMPLETED
Hypomagnesemia and Its Association With Calcineurin Inhibitors Use in Renal Transplant Recipients nanCOMPLETED
An Investigation Into the Mechanism of Inhalation Cough Challenge nanCOMPLETED
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain. nanUNKNOWN
The Natural History of TRPV4 Neuropathy nanRECRUITING
Effects of an Anti-TRPM8 in the Atopic Dermatitis Pruritus nanCOMPLETED
Dissecting the Heterogeneity of Oral Cancer Pain nanUNKNOWN
Relationship Between Polymorphisms of TRPV1 and KCC2 Gene in Children With Febrile Seizures nanCOMPLETED
Effects of Photobiomodulation on the Innate Immune System of Neonates and Infants With Bronchiolitis nanUNKNOWN
Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) in Ischaemic, Inflammatory and Takotsubo Cardiomyopathy (MEMORY) nanCOMPLETED
Investigation of a New Human Model for Itch nanCOMPLETED
Neurogenic Mechanisms in Burning Mouth Syndrome nanCOMPLETED
Qutenza 8% Capsaicin Topical System for the Treatment of Neuropathic Axial Lower Back Pain and Lumbosacral Radiculopathy nanENROLLING_BY_INVITATION

Related proteins — ESM-2 sequence neighbours (a TRPM2 binder may also engage these)

ProteinNameSimilarity
Q91YD4 — 1.000 Q91YD4 →
E9PTA2 — 1.000 E9PTA2 →
TRPM5 Transient receptor potential cation channel subfamily M member 5 0.977 landscape →
Q9JMI9 — 0.975 Q9JMI9 →
Q4R4U1 — 0.973 Q4R4U1 →
Q9JJH7 — 0.973 Q9JJH7 →
Q9QZC1 — 0.973 Q9QZC1 →
Q5R5F8 — 0.969 Q5R5F8 →
Q9NVE7 — 0.968 Q9NVE7 →
Q9R283 — 0.967 Q9R283 →
TRPC3 Short transient receptor potential channel 3 0.966 landscape →
Q923S8 — 0.965 Q923S8 →
TRPC6 Short transient receptor potential channel 6 0.964 landscape →
Q99J78 — 0.964 Q99J78 →
Q96RR1 — 0.962 Q96RR1 →
Q6DFV5 — 0.961 Q6DFV5 →
Q4V8I4 — 0.960 Q4V8I4 →
A5PJM7 — 0.960 A5PJM7 →
Q9WVC5 — 0.960 Q9WVC5 →
Q6NYU2 — 0.959 Q6NYU2 →
Q04671 — 0.959 Q04671 →
Q61143 — 0.958 Q61143 →
Q9MYW0 — 0.958 Q9MYW0 →
Q8CIW5 — 0.957 Q8CIW5 →
HELZ Probable helicase with zinc finger domain 0.957 landscape →
TRPC7 Short transient receptor potential channel 7 0.957 landscape →
Q9TU72 — 0.956 Q9TU72 →
Q6DDJ3 — 0.955 Q6DDJ3 →
Q5R5M3 — 0.955 Q5R5M3 →
Q80YV4 — 0.955 Q80YV4 →