Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 15/20 | 0.67 |
| ▸ | ADORA1 | P30542 | 14/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 9/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1255219 | 0.92 | ADORA1 (0.57) | ADORA2AADORA1ADORA3KDM4ENPC1 | |
| SCHEMBL1255640 | 0.88 | ADORA2A (0.68) | ADORA2AADORA1ADORA3KDM4ENPC1 | |
| SCHEMBL1256007 | 0.85 | ADORA2A (0.77) | ADORA2AADORA1ADORA3 | |
| SCHEMBL1256952 | 0.84 | ADORA2A (0.62) | ADORA2AADORA1ADORA3 | |
| SCHEMBL1255443 | 0.83 | ADORA2A (0.62) | ADORA2AADORA1ADORA3 | |
| SCHEMBL1256080 | 0.83 | ADORA2A (0.62) | ADORA2AADORA1ADORA3 | |
| SCHEMBL1254337 | 0.83 | ADORA2A (0.64) | ADORA2AADORA1ADORA3KDM4ENPC1 | |
| SCHEMBL1256085 | 0.83 | ADORA2A (0.53) | ADORA2AADORA1ADORA3 | |
| SCHEMBL1255377 | 0.82 | ADORA2A (0.62) | ADORA2AADORA1ADORA3 | |
| SCHEMBL1256862 | 0.82 | ADORA2A (0.71) | ADORA2AADORA1ADORA3KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889718-B2 | Thiazole derivatives | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2014-11-18 | — | — | US | disclosed |
| US-8420827-B2 | Thiazole derivatives | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2013-04-16 | — | — | US | disclosed |