Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 6/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8164137 | 0.80 | ALDH1A1 (0.37) | FFAR1FFAR4KMT2AALDH1A1POLB | |
| SCHEMBL14864875 | 0.73 | GAA (0.42) | ALDH1A1POLBMAPTGAALMNA | |
| SCHEMBL14864870 | 0.72 | GAA (0.44) | ALDH1A1MAPTGAALMNAL3MBTL1 | |
| SCHEMBL13236920 | 0.68 | GAA (0.63) | KMT2AALDH1A1POLBMEN1MAPT | |
| SCHEMBL13241732 | 0.65 | ALDH1A1 (0.63) | KMT2AALDH1A1MEN1MAPTKDM4E | |
| SCHEMBL701594 | 0.65 | MAPT (0.57) | KMT2AALDH1A1MEN1MAPTKDM4E | |
| SCHEMBL29978606 | 0.65 | MAPT (0.57) | KMT2AALDH1A1MEN1MAPTKDM4E | |
| SCHEMBL7566464 | 0.64 | POLB (0.59) | KMT2AALDH1A1POLBMEN1MAPT | |
| SCHEMBL14864874 | 0.64 | ALDH1A1 (0.55) | KMT2AALDH1A1POLBMEN1MAPT | |
| SCHEMBL3642120 | 0.64 | ALDH1A1 (0.41) | KMT2AALDH1A1POLBMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420830-B2 | Macrocyclic factor VIIa inhibitors useful as anticoagulants | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-04-16 | — | — | US | disclosed |