Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 19/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL171929 | 0.86 | GRM2 (1.00) | GRM2KDM4EALDH1A1MAPK1 | |
| SCHEMBL171735 | 0.84 | GRM2 (0.65) | GRM2 | |
| SCHEMBL171830 | 0.79 | GRM2 (0.74) | GRM2 | |
| SCHEMBL171787 | 0.79 | GRM2 (0.77) | GRM2 | |
| SCHEMBL100657 | 0.79 | GRM2 (1.00) | GRM2 | |
| SCHEMBL171937 | 0.77 | GRM2 (0.84) | GRM2 | |
| SCHEMBL5448385 | 0.77 | GRM2 (0.64) | GRM2 | |
| SCHEMBL101093 | 0.76 | GRM2 (0.69) | GRM2 | |
| SCHEMBL103628 | 0.76 | GRM2 (1.00) | GRM2 | |
| SCHEMBL171799 | 0.76 | GRM2 (0.82) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994004-B9 | 1,4-DISUBSTITUTED 3-CYANO-PYRIDONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS | JANSSEN PHARMACEUTICALS INC (US) | 2013-04-17 | — | — | EP | disclosed |