Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.69 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.57 |
| ▸ | RXRA | P19793 | 5/20 | 0.56 |
| ▸ | RXRB | P28702 | 5/20 | 0.56 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.56 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | RXRG | P48443 | 1/20 | 0.53 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.50 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.50 |
| ▸ | RARA | P10276 | 1/20 | 0.50 |
| ▸ | RARB | P10826 | 1/20 | 0.50 |
| ▸ | RARG | P13631 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6715356 | 0.88 | BCL2 (0.62) | BCL2NR4A2RXRARXRBAOC3 | |
| SCHEMBL4440879 | 0.85 | MRGPRX4 (0.71) | NR4A2MRGPRX4 | |
| SCHEMBL14715123 | 0.83 | NPC1 (0.57) | RXRARXRBRXRGRARARARB | |
| SCHEMBL791844 | 0.83 | AGXT (0.66) | BCL2NR4A2MRGPRX4 | |
| SCHEMBL13232626 | 0.82 | BCL2 (0.55) | BCL2RARARARBRARG | |
| SCHEMBL12894973 | 0.82 | BCL2 (1.00) | BCL2RXRARXRBAOC3RXRG | |
| SCHEMBL30628893 | 0.82 | MRGPRX4 (0.67) | MRGPRX4 | |
| SCHEMBL565902 | 0.82 | MRGPRX4 (0.67) | MRGPRX4 | |
| SCHEMBL6715240 | 0.81 | NR4A2 (0.48) | BCL2NR4A2MRGPRX4EGFR | |
| SCHEMBL1338378 | 0.81 | AGXT (0.53) | BCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994004-B9 | 1,4-DISUBSTITUTED 3-CYANO-PYRIDONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS | JANSSEN PHARMACEUTICALS INC (US) | 2013-04-17 | — | — | EP | disclosed |