Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 16/20 | 0.51 |
| ▸ | HRH1 | P35367 | 11/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.51 |
| ▸ | HTR2A | P28223 | 4/20 | 0.51 |
| ▸ | HTR2C | P28335 | 4/20 | 0.51 |
| ▸ | HTR7 | P34969 | 4/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.51 |
| ▸ | DRD2 | P14416 | 3/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.46 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13233206 | 0.85 | HTR6 (0.53) | HTR6HRH1ADRA2AHTR2AHTR2C | |
| SCHEMBL14716451 | 0.79 | HTR6 (0.48) | HTR6HRH1ADRA2AHTR2AHTR2C | |
| SCHEMBL13665758 | 0.76 | HTR6 (0.56) | HTR6HRH1ADRA2AHTR2AHTR2C | |
| SCHEMBL13665492 | 0.76 | HTR6 (0.56) | HTR6HRH1ADRA2AHTR2AHTR2C | |
| SCHEMBL13654472 | 0.76 | HTR6 (0.43) | HTR6HRH1ADRA2AHTR2AHTR2C | |
| SCHEMBL25056609 | 0.76 | HTR6 (0.64) | HTR6HRH1ADRA2AHTR2AHTR2C | |
| SCHEMBL30095919 | 0.76 | HTR6 (0.64) | HTR6HRH1ADRA2AHTR2AHTR2C | |
| SCHEMBL18155177 | 0.75 | HTR6 (0.47) | HTR6HRH1ADRA2AHTR2AHTR2C | |
| SCHEMBL1120515 | 0.75 | PTGDR2 (0.60) | HTR6HRH1ADRA2AHTR2AHTR2C | |
| SCHEMBL1120722 | 0.74 | HRH1 (0.56) | HTR6HRH1ADRA2AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994004-B9 | 1,4-DISUBSTITUTED 3-CYANO-PYRIDONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS | JANSSEN PHARMACEUTICALS INC (US) | 2013-04-17 | — | — | EP | disclosed |