Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 5/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 2/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2810317 | 0.92 | BDKRB1 (0.60) | BDKRB1MAPK11MAPK14HDAC1HDAC6 | |
| SCHEMBL2806049 | 0.82 | BDKRB1 (0.62) | BDKRB1MAPK11MAPK14HDAC1HDAC6 | |
| SCHEMBL185457 | 0.80 | BDKRB1 (0.49) | BDKRB1HDAC1HDAC6CTSL | |
| SCHEMBL2805903 | 0.74 | BDKRB1 (0.63) | BDKRB1MAPK11MAPK14CNR1CTSL | |
| SCHEMBL2810040 | 0.74 | BDKRB1 (0.58) | BDKRB1MAPK11MAPK14CNR1CTSL | |
| SCHEMBL2805998 | 0.73 | BDKRB1 (0.57) | BDKRB1MAPK11MAPK14CNR1CTSL | |
| SCHEMBL764413 | 0.73 | BDKRB1 (0.64) | BDKRB1MAPK11MAPK14HDAC1HDAC6 | |
| SCHEMBL2548562 | 0.72 | BDKRB1 (0.62) | BDKRB1MAPK11MAPK14CNR1CTSL | |
| SCHEMBL2806959 | 0.71 | BDKRB1 (0.59) | BDKRB1HDAC1HDAC6L3MBTL1SMN1; SMN2 | |
| SCHEMBL10121331 | 0.70 | BDKRB1 (0.60) | BDKRB1MAPK11MAPK14CNR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |