Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 3/20 | 0.49 |
| ▸ | FAAH | O00519 | 8/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL187120 | 0.90 | BDKRB1 (0.50) | BDKRB1FAAHTRPV1NPC1RAB9A | |
| SCHEMBL2810317 | 0.87 | BDKRB1 (0.60) | BDKRB1CTSLCTSBCTSSOPRM1 | |
| SCHEMBL184989 | 0.83 | BDKRB1 (0.50) | BDKRB1FAAHTRPV1 | |
| SCHEMBL185880 | 0.82 | BDKRB1 (0.47) | BDKRB1FAAHTRPV1NPC1RAB9A | |
| SCHEMBL185085 | 0.82 | BDKRB1 (0.47) | BDKRB1FAAHTRPV1NPC1RAB9A | |
| SCHEMBL185841 | 0.81 | BDKRB1 (0.46) | BDKRB1FAAHTRPV1 | |
| SCHEMBL14865356 | 0.80 | BDKRB1 (0.52) | BDKRB1CTSLHDAC1HDAC6 | |
| SCHEMBL14856425 | 0.77 | BDKRB1 (0.48) | BDKRB1FAAHTRPV1NPC1RAB9A | |
| SCHEMBL2806049 | 0.77 | BDKRB1 (0.62) | BDKRB1CTSLCTSBCTSSHDAC1 | |
| SCHEMBL758571 | 0.77 | BDKRB1 (0.47) | BDKRB1FAAHTRPV1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |